{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T05:48:28Z","timestamp":1775195308074,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T00:00:00Z","timestamp":1698624000000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5K23GM122069"],"award-info":[{"award-number":["5K23GM122069"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL148712"],"award-info":[{"award-number":["R01HL148712"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 HL\u2010110849\u201009"],"award-info":[{"award-number":["T32 HL\u2010110849\u201009"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016251","name":"Hemophilia Center of Western Pennsylvania","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016251","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["15SDG24910003"],"award-info":[{"award-number":["15SDG24910003"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002590","name":"American Lung Association","doi-asserted-by":"publisher","award":["RG\u2010515656"],"award-info":[{"award-number":["RG\u2010515656"]}],"id":[{"id":"10.13039\/100002590","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","award":["Research Scholars Program"],"award-info":[{"award-number":["Research Scholars Program"]}],"id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pulm. circ."],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Pulmonary hypertension (PH) is common in advanced heart failure and often improves quickly after left ventricular assist device (VAD) implantation or orthotopic heart transplantation (OHT), but long\u2010term effects and outcomes are not well\u2010described. This study evaluated PH persistence after VAD as destination therapy (VAD\u2010DT), bridge to transplant (VAD\u2010OHT), or OHT\u2010alone. The study constituted a retrospective review of patients who underwent VAD\u2010DT (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009164), VAD\u2010OHT (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009111), or OHT\u2010alone (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009138) at a single tertiary\u2010care center. Right heart catheterization (RHC) data was collected pre\u2010, post\u2010intervention (VAD and\/or OHT), and 1\u2010year from final intervention (latest\u2010RHC) to evaluate the longitudinal hemodynamic course of right ventricular\u00a0function and pulmonary vasculature. PH (Group\u00a0II and Group I) definitions were adapted from expert guidelines. All groups showed significant improvements in mean pulmonary artery pressure (mPAP), pulmonary artery wedge pressure (PAWP), cardiac output,\u00a0and pulmonary vascular resistance (PVR) at each RHC with greatest improvement at post\u2010intervention RHC (post\u2010VAD or post\u2010OHT). PH was reduced from 98% to 26% in VAD\u2010OHT, 92%\u221249% in VAD\u2010DT, and 76%\u221228% in OHT\u2010alone from preintervention to latest\u2010RHC. At latest\u2010RHC mPAP remained elevated in all groups despite normalization of PAWP and PVR. VAD\u2010supported patients exhibited suppressed pulmonary artery pulsatility index (PaPi\u2009&lt;\u20093.7) with improvement only posttransplant at latest\u2010RHC. Posttransplant patients with PH at latest\u2010RHC (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200960) exhibited lower survival (HR: 2.1 [95%\u00a0CI: 1.3\u22123.4],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Despite an overall significant improvement in pulmonary pressures and PH proportion, a notable subset of patients exhibited PH post\u2010intervention. Post\u2010intervention PH was associated with lower posttransplant survival.\n                  <\/jats:p>","DOI":"10.1002\/pul2.12296","type":"journal-article","created":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T07:58:59Z","timestamp":1698652739000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Persistence of pulmonary hypertension in patients undergoing ventricular assist devices and orthotopic heart transplantation"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1085-3827","authenticated-orcid":false,"given":"Arun","family":"Rajaratnam","sequence":"first","affiliation":[{"name":"Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ameen","family":"El\u2010Swais","sequence":"additional","affiliation":[{"name":"University of Kansas School of Medicine  Wichita Kansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"McTiernan","sequence":"additional","affiliation":[{"name":"Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Department of Medicine, Division of Cardiology University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Floyd W.","family":"Thoma","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moaaz O.","family":"Baghal","sequence":"additional","affiliation":[{"name":"Department of Cardiology Mercy Health St. Vincent's Medical Center  Toledo Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristen","family":"Raffensperger","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Pulmonary Allergy and Critical Care Medicine University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung\u2010Chou H.","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of General Internal Medicine University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gavin W.","family":"Hickey","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faraaz A.","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Pulmonary Allergy and Critical Care Medicine University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0386-5360","authenticated-orcid":false,"given":"Imad","family":"Al Ghouleh","sequence":"additional","affiliation":[{"name":"Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Department of Medicine, Division of Cardiology University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"},{"name":"Department of Pharmacology and Chemical Biology University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania 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