{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T22:53:51Z","timestamp":1771541631953,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T00:00:00Z","timestamp":1696982400000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pulm. circ."],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pulmonary hypertension (PH) is a risk factor for mortality in patients with sarcoidosis. Severe PH in chronic lung disease has previously been defined as mean pulmonary arterial pressure (mPAP)\u2009\u2265\u200935\u2009mmHg or mPAP 25\u2009\u2265\u2009mmHg with cardiac index (CI)\u2009\u2264\u20092\u2009L\/min\/m<jats:sup>2<\/jats:sup>. However, there is no clear definition denoting severity of sarcoidosis\u2010associated PH (SAPH). We aimed to determine pulmonary hemodynamic cut\u2010off values where transplant\u2010free survival was worse among patients with SAPH. This was a retrospective cohort analysis of the Registry of SAPH database focusing on pulmonary hemodynamic predictors of transplant\u2010free survival among patients with precapillary SAPH. Cox regression was performed to determine which pulmonary hemodynamic values predicted death or lung transplantation. Kaplan\u2212Meier survival analysis was performed on statistically significant predictors to determine pulmonary hemodynamic cut\u2010off values where transplant\u2010free survival was decreased. Decreased transplant\u2010free survival occurred among SAPH patients with mPAP \u2265 40\u2009mmHg and SAPH patients with pulmonary vascular resistance (PVR)\u2009\u2265\u20095 Woods units (WU). Transplant\u2010free survival was not decreased in patients who fulfilled prior criteria of severe PH in chronic lung disease. We identified new cut\u2010offs with decreased transplant\u2010free survival in the SAPH population. Neither cut\u2010off of mPAP \u2265 40\u2009mmHg nor PVR\u2009\u2265\u20095 WU has previously been shown to be associated with decreased transplant\u2010free survival in SAPH. These values could suggest a new definition of severe SAPH. Our PVR findings are in line with the most recent European Society of Cardiology\/European Respiratory Society guideline definition of severe PH in chronic lung disease.<\/jats:p>","DOI":"10.1002\/pul2.12297","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T07:15:58Z","timestamp":1697094958000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Pulmonary hemodynamics and transplant\u2010free survival in sarcoidosis\u2010associated pulmonary hypertension: Results from an international registry"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0275-7416","authenticated-orcid":false,"given":"Shameek K.","family":"Gayen","sequence":"first","affiliation":[{"name":"Department of Thoracic Medicine and Surgery Lewis Katz School of Medicine at Temple University Hospital  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert P.","family":"Baughman","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Cincinnati Medical Center  Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven D.","family":"Nathan","sequence":"additional","affiliation":[{"name":"The Advanced Lung Disease and Transplant Program Inova Fairfax Hospital  Falls Church Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athol U.","family":"Wells","sequence":"additional","affiliation":[{"name":"Interstitial Lung Disease\/Sarcoidosis unit Royal Brompton Hospital, National Heart and Lung Institute, Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasilis","family":"Kouranos","sequence":"additional","affiliation":[{"name":"Interstitial Lung Disease\/Sarcoidosis unit Royal Brompton Hospital, National Heart and Lung Institute, Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esam H.","family":"Alhamad","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine, College of Medicine King Saud University  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel A.","family":"Culver","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, and Department of Inflammation and Immunity Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Barney","sequence":"additional","affiliation":[{"name":"The University of Alabama at Birmingham School of Medicine  Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva M.","family":"Carmoma","sequence":"additional","affiliation":[{"name":"Pulmonary and Critical Care, Mayo Clinic Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis C.","family":"Cordova","sequence":"additional","affiliation":[{"name":"Department of Thoracic Medicine and Surgery Lewis Katz School of Medicine at Temple University Hospital  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marloes","family":"Huitema","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sint Antonius Hospital  Nieuwegein Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Beth","family":"Scholand","sequence":"additional","affiliation":[{"name":"University of Utah School of Medicine  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marlies","family":"Wijsenbeek","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Centre of Excellence for Interstitial Lung Diseases and Sarcoidosis, Erasmus Medical Centre  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sivagini","family":"Ganesh","sequence":"additional","affiliation":[{"name":"Pulmonary, Critical Care and Sleep Medicine Keck School of Medicine of the University of Southern California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Surinder S.","family":"Birring","sequence":"additional","affiliation":[{"name":"Centre for Human &amp; 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