{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:15:54Z","timestamp":1787066154856,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:00:00Z","timestamp":1715731200000},"content-version":"vor","delay-in-days":44,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pulm. circ."],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Surgical indications for patients with pulmonary arterial hypertension (PAH) and congenital heart defects are controversial. The treat and repair strategy has demonstrated efficacy in adult populations, but there have been no studies on pediatric patients. This study included pediatric patients with PAH and simple congenital heart defects who underwent corrective repair between 2012 and 2021. According to the preoperative treatment strategies, the patients were divided into a regular strategy group (Group 1) and a treat\u2010and\u2010repair strategy group (Group 2). Postoperative recovery and follow\u2010up results were compared between the two groups. A total of 33 patients were included in this study. Group 1 consisted of 19 patients, whereas Group 2 consisted of 14 patients. The pulmonary vascular resistance index in Group 2 was higher than that in Group 1 (10.9\u2009\u00b1\u20094.1 vs. 8.2\u2009\u00b1\u20091.6 WU,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.031). There were no differences in postoperative recovery between the two groups (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&gt;\u20090.05). During follow\u2010up, five patients were lost (three in Group 1 and two in Group 2). The median follow\u2010up period was 59 months. One patient died in Group 1, and two patients died in Group 2. There was no significant difference in the survival curve (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.39). At the last follow\u2010up, another seven patients had experienced a non\u2010low\u2010risk condition, with a total of three non\u2010low\u2010risk patients in Group 1 and seven in Group 2, including one patient in each group who had a history of ICU admission. According to the ROC curve, a preoperative PVRi &lt;8.2\u2009WU\u00d7m\n                    <jats:sup>2<\/jats:sup>\n                    can predict postoperative persistent low\u2010risk state, PVRi &lt;5.2\u2009WU\u00d7m\n                    <jats:sup>2<\/jats:sup>\n                    can avoid postoperative death and\/or ICU administration. In pediatric patients with PAH and simple congenital heart defects, the treat and repair strategies may provide surgery opportunities, PVRi should be &lt;8\u2009WU\u00d7m\n                    <jats:sup>2<\/jats:sup>\n                    , and &lt;5.2\u2009WU\u00d7m\n                    <jats:sup>2<\/jats:sup>\n                    is the best choice.\n                  <\/jats:p>","DOI":"10.1002\/pul2.12387","type":"journal-article","created":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T08:28:41Z","timestamp":1715761721000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Therapeutic effects of treat and repair strategy in pediatric patients with pulmonary arterial hypertension and simple congenital heart defects"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0833-0218","authenticated-orcid":false,"given":"Xiaofeng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pediatric Intensive Care Unit, National Center for Cardiovascular Disease, FuWai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care Unit, National Center for Cardiovascular Disease, FuWai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyuan","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care Unit, National Center for Cardiovascular Disease, FuWai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenlong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care Unit, National Center for Cardiovascular Disease, FuWai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care Unit, National Center for Cardiovascular Disease, FuWai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,15]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61922-X"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2017-312106"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2018.07.017"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2008.150086"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.recesp.2016.01.002"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2023.02.1494"},{"issue":"4","key":"e_1_2_12_8_1","first-page":"315","article-title":"Risk factors for death and the clinical features of different subtypes of patients with pulmonary arterial hypertension related to congenital heart disease","volume":"48","author":"Xu ZY","year":"2020","journal-title":"Zhonghua Xin Xue Guan Bing Za Zhi"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2019.06.022"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pul2.12067"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa554"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.02.031"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.4402"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2019.03.056"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2021-319096"},{"issue":"2","key":"e_1_2_12_16_1","first-page":"033","article-title":"Treat\u2010and\u2010repair strategy is a feasible therapeutic choice in adult patients with severe pulmonary arterial hypertension associated with a ventricular septal defect: case series","volume":"2","author":"Akagi S","year":"2018","journal-title":"Eur Heart J Case Rep"},{"issue":"7","key":"e_1_2_12_17_1","first-page":"1165","article-title":"Midterm results of \u201ctreat and repair\u201d for adults with non\u2010restrictive ventricular septal defect and severe pulmonary hypertension","volume":"7","author":"Hu Z","year":"2015","journal-title":"J Thorac Dis"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezac347"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.2217\/fca-2017-0065"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2019.12.070"}],"container-title":["Pulmonary Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pul2.12387","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T01:38:07Z","timestamp":1720143487000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pul2.12387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1002\/pul2.12387"],"URL":"https:\/\/doi.org\/10.1002\/pul2.12387","archive":["Portico"],"relation":{},"ISSN":["2045-8940","2045-8940"],"issn-type":[{"value":"2045-8940","type":"print"},{"value":"2045-8940","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"2023-10-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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