{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T22:33:37Z","timestamp":1788561217063,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T00:00:00Z","timestamp":1718582400000},"content-version":"vor","delay-in-days":77,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pulm. circ."],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Data on demographic characteristics and therapeutic approaches in Latin American pulmonary arterial hypertension (PAH) patients are scarce. Pulmonary Hypertension Mexican registry (REMEHIP) is a multicenter Mexican registry of adult and pediatric patients, including prevalent and incident cases. Objective: assess clinical characteristics, treatment trends, and in\u2010hospital outcomes. Inclusion: age &gt;2 years, diagnosis of pulmonary hypertension\u00a0(PH) (groups 1 and 4),\u00a0right heart catheterization with mPAP \u226525\u2009mmHg, PWP\u2009\u2264\u200915\u2009mmHg, and PVR\u2009&gt;\u20093 Wood unit\u00a0(WU). We included 875 PH patients, 619 adults, 133 pediatric idiopathic PAH (IPAH), and 123 chronic thromboembolic pulmonary hypertension (CTEPH) patients. We enrolled 48.4% of the incident and 51.6% of the prevalent adult and pediatric patients. PAH adults: age 43\u2009\u00b1\u200915, females 81.9%, functional class (FC) (I\/II) 66.5%, 6\u2010min walk distance (6MWD)\u00a0378\u2009\u00b1\u2009112\u2009m, mPAP 57.3\u2009\u00b1\u200919.0\u2009mmHg, confidence interval (CI) 3.3\u2009\u00b1\u20091.5\u2009L\/min\/m<jats:sup>2<\/jats:sup>, PVR 12.0\u2009\u00b1\u20098.1 WU. PAH pediatrics: age 9\u2009\u00b1\u20095, females 51.1%, FC (I\/II) 85.5%, 6MWD 376\u2009\u00b1\u2009103\u2009m, mPAP 49.7\u2009\u00b1\u200913.4\u2009mmHg, CI 2.6\u2009\u00b1\u20090.9\u2009L\/min\/m<jats:sup>2<\/jats:sup>, PVR 16.4\u2009\u00b1\u200913.5 WU. CTEPH: age 44\u2009\u00b1\u200917, females 56.1%, FC (I\/II) 65.5%, 6MWD 369\u2009\u00b1\u2009126\u2009m, mPAP 49.7\u2009\u00b1\u200913.4\u2009mmHg, CI 2.6\u2009\u00b1\u20090.9\u2009L\/min\/m<jats:sup>2<\/jats:sup>, PVR 10.5\u2009+\u20096.5 WU. When we analyzed the IPAH group separately, it sustained a high functional class I\/II incidence. REMEHIP shows better functional class in young females with severe PAH than in American and European patients. Also, PAH pediatric patients had a better functional class than other registries. However, our registry also shows that our population's access to specific pharmacologic treatments is still far from optimal.<\/jats:p>","DOI":"10.1002\/pul2.12395","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T13:54:02Z","timestamp":1718632442000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Demographic, hemodynamic characteristics, and therapeutic trends of pulmonary hypertension patients: The Pulmonary Hypertension Mexican registry (REMEHIP)"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3222-7405","authenticated-orcid":false,"given":"Carlos","family":"Jerjes\u2010S\u00e1nchez","sequence":"first","affiliation":[{"name":"Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud  Monterrey Nuevo Leon Mexico"},{"name":"Instituto de Cardiolog\u00eda y Medicina Vascular, TecSalud  San Pedro Garza Garcia Nuevo Leon Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4535-9610","authenticated-orcid":false,"given":"Alicia","family":"Ram\u00edrez\u2010Rivera","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n Cl\u00ednica en Medicina\u00a0S.C.  Monterrey Nuevo Leon Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayeli Zayas","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Cardiolog\u00eda Ignacio Chavez  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3217-1595","authenticated-orcid":false,"given":"Guillermo","family":"Cueto Robledo","sequence":"additional","affiliation":[{"name":"Hospital General de M\u00e9xico  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2519-0096","authenticated-orcid":false,"given":"Humberto","family":"Garc\u00eda\u2010Aguilar","sequence":"additional","affiliation":[{"name":"Centro M\u00e9dico Nacional 20 de noviembre, ISSSTE  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2864-8701","authenticated-orcid":false,"given":"Pedro","family":"Guti\u00e9rrez\u2010Fajardo","sequence":"additional","affiliation":[{"name":"Cardiotest, Laboratorio de Ecocardiograf\u00eda  Guadalajara Jalisco Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Seoane Garc\u00eda de Le\u00f3n","sequence":"additional","affiliation":[{"name":"Centro M\u00e9dico ABC  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9206-8736","authenticated-orcid":false,"given":"Francisco","family":"Moreno Hoyos\u2010Abril","sequence":"additional","affiliation":[{"name":"Hospital Universitario \u201cDr. Jos\u00e9 E. Gonz\u00e1lez\u201d UANL  Monterrey Nuevo Leon Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3480-000X","authenticated-orcid":false,"given":"Miguel","family":"Ernesto Beltr\u00e1n G\u00e1mez","sequence":"additional","affiliation":[{"name":"Hospital Angeles de Tijuana  Tijuana Baja California Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Elizalde","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1442-7673","authenticated-orcid":false,"given":"Tom\u00e1s Pulido","family":"Fccp","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Cardiolog\u00eda Ignacio Chavez  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6825-3600","authenticated-orcid":false,"given":"Julio","family":"Sandoval","sequence":"additional","affiliation":[{"name":"Centro M\u00e9dico ABC  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The REMEHIP Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,17]]},"reference":[{"issue":"1","key":"e_1_2_12_2_1","first-page":"13","article-title":"Mexican registry of pulmonary hypertension","volume":"87","author":"Sandoval Zarate J","year":"2017","journal-title":"Arch Cardiol Mex"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-1140"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200510-1668OC"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.89.4.1733"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.14-1036"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-016-9842-y"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/2045894019847643"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/1817-1737.140127"},{"issue":"2","key":"e_1_2_12_10_1","first-page":"115","article-title":"Iranian pulmonary arterial hypertension registry","volume":"14","author":"Masjedi MR","year":"2015","journal-title":"Tanaffos"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12881-018-0608-7"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.2000.2265"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp596"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv317"},{"key":"e_1_2_12_15_1","article-title":"2022 ESC\/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension","author":"Humbert M","year":"2022","journal-title":"Eur Heart J"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-2327"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201203-0383OC"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00101211"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.119.6.1801"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2008.150086"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acvd.2009.12.001"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.026591"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61621-8"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000138104.83366.E9"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-2960"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2019.10.008"},{"key":"e_1_2_12_27_1","first-page":"148","article-title":"Clinical hemodynamic correlation of the NYHA\/WHO system in idiopathic pulmonary artery hypertension. 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