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Here we performed an observational study in which food and supplement consumption were collected in an observation period followed by open label administration of a carnitine supplement to determine feasibility of increasing plasma carnitine levels in humans PAH. We confirmed that relative carnitine deficiency in PAH is not due to reduced dietary consumption and that plasma levels of carnitine can be increased in PAH patients with supplementation that is well tolerated.<\/jats:p>","DOI":"10.1002\/pul2.12425","type":"journal-article","created":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T05:24:00Z","timestamp":1723785840000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Carnitine consumption and effect of oral supplementation in human pulmonary arterial hypertension: A pilot study"],"prefix":"10.1002","volume":"14","author":[{"given":"Evan L.","family":"Brittain","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisha","family":"Lindsey","sequence":"additional","affiliation":[{"name":"Division of Allergy, Pulmonary and Critical Care Medicine Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Burke","sequence":"additional","affiliation":[{"name":"Division of Allergy, Pulmonary and Critical Care Medicine Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8457-6722","authenticated-orcid":false,"given":"Vineet","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Robbins","sequence":"additional","affiliation":[{"name":"Division of Allergy, Pulmonary and Critical Care Medicine Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith","family":"Pugh","sequence":"additional","affiliation":[{"name":"Division of Allergy, Pulmonary and Critical Care Medicine Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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