{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:09:13Z","timestamp":1753870153317,"version":"3.41.2"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T00:00:00Z","timestamp":1723680000000},"content-version":"vor","delay-in-days":45,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pulm. circ."],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The prognostic significance of pretransplant N\u2010terminal pro\u2010brain (B)\u2010type natriuretic peptide (NT\u2010proBNP) level has not been investigated in lung transplant recipients. The electronic files of 173 patients with chronic lung disease who underwent lung transplantation in 2018\u20132022 at a tertiary medical center were retrospectively reviewed. Right heart catheterization (RHC) and NT\u2010proBNP determination were performed preoperatively in all cases. Pretransplant demographic, clinical, and laboratory data were compared between posttransplant survivors and nonsurvivors. Correlations of NT\u2010proBNP values with lung function and RHC parameters and all\u2010cause mortality were analyzed. NT\u2010proBNP level correlated positively with mean pulmonary artery pressure (<jats:italic>R<\/jats:italic>\u2009=\u20090.51, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and pulmonary vascular resistance (PVR) (<jats:italic>R<\/jats:italic>\u2009=\u20090.45, <jats:italic>p<\/jats:italic>\u2009=\u20090.0013), and negatively with diffusing lung capacity for carbon monoxide (<jats:italic>R<\/jats:italic>\u2009=\u2009\u22120.25, <jats:italic>p<\/jats:italic>\u2009=\u20090.0017), cardiac index (<jats:italic>R<\/jats:italic>\u2009=\u2009\u22120.26, <jats:italic>p<\/jats:italic>\u2009=\u20090.001), and cardiac output (<jats:italic>R<\/jats:italic>\u2009=\u2009\u22120.23, <jats:italic>p<\/jats:italic>\u2009=\u20090.004). Over a median follow\u2010up time of 23.22 months, 74 patients died. On univariate analysis, mortality was significantly associated with higher log\u2010NT\u2010proBNP (hazard ratio [HR]\u2009=\u20090.54, 95% confidence interval [CI] 1.15\u20132.05, <jats:italic>p<\/jats:italic>\u2009=\u20090.016), older age at transplant registration (HR\u2009=\u20091.033, 95% CI 1.009\u20131.058, <jats:italic>p<\/jats:italic>\u2009=\u20090.0068), higher PVR (HR 1.15, 95% CI 1.07\u20131.23, <jats:italic>p<\/jats:italic>\u2009=\u20090.015), and lower cardiac output (HR\u2009=\u20090.62, 95% CI 0.42\u20130.92, <jats:italic>p<\/jats:italic>\u2009=\u20090.045). On multivariate analysis adjusted for age, sex, and body mass index, mortality significance was maintained only for higher log\u2010NT\u2010proBNP (HR\u2009=\u20091.54, 95% CI 1.12\u20132.11, <jats:italic>p<\/jats:italic>\u2009=\u20090.007). Among lung transplant recipients, pretransplant NT\u2010proBNP levels correlated well with RHC parameters and were strongly associated with posttransplantation mortality. Assessment of NT\u2010proBNP may improve risk stratification of lung transplant candidates.<\/jats:p>","DOI":"10.1002\/pul2.12427","type":"journal-article","created":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T05:24:04Z","timestamp":1723785844000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pretransplant NT\u2010proBNP levels are associated with mortality among lung transplant recipients"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1150-1057","authenticated-orcid":false,"given":"Shimon","family":"Izhakian","sequence":"first","affiliation":[{"name":"Rabin Medical Center\u2014Beilinson Hospital, Pulmonary Institute  Petach Tikva Israel"},{"name":"Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Assaf","family":"Frajman","sequence":"additional","affiliation":[{"name":"Rabin Medical Center\u2014Beilinson Hospital, Pulmonary Institute  Petach Tikva Israel"},{"name":"Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariel D.","family":"Hayat","sequence":"additional","affiliation":[{"name":"Rabin Medical Center\u2014Beilinson Hospital, Pulmonary Institute  Petach Tikva Israel"},{"name":"The Adelson School of Medicine Ariel University  Ariel Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7542-8608","authenticated-orcid":false,"given":"Alon","family":"Gorenshtein","sequence":"additional","affiliation":[{"name":"Rabin Medical Center\u2014Beilinson Hospital, Pulmonary Institute  Petach Tikva Israel"},{"name":"Azrieli Faculty of Medicine Bar\u2010Ilan University  Safed Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osnat","family":"Shtraichman","sequence":"additional","affiliation":[{"name":"Rabin Medical Center\u2014Beilinson Hospital, Pulmonary Institute  Petach Tikva Israel"},{"name":"Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lev","family":"Freidkin","sequence":"additional","affiliation":[{"name":"Rabin Medical Center\u2014Beilinson Hospital, Pulmonary Institute  Petach Tikva Israel"},{"name":"Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dror","family":"Rosengarten","sequence":"additional","affiliation":[{"name":"Rabin Medical Center\u2014Beilinson Hospital, Pulmonary Institute  Petach Tikva Israel"},{"name":"Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mordechai R.","family":"Kramer","sequence":"additional","affiliation":[{"name":"Rabin Medical Center\u2014Beilinson Hospital, Pulmonary Institute  Petach Tikva Israel"},{"name":"Faculty of Medicine Tel 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