{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:48:42Z","timestamp":1793148522020,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:00:00Z","timestamp":1733270400000},"content-version":"vor","delay-in-days":64,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pulm. circ."],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Macitentan is a dual endothelin receptor antagonist (ERA) approved for treating pulmonary arterial hypertension (PAH). SOPRANO evaluated the efficacy and safety of macitentan versus placebo in pulmonary hypertension (PH) patients after left ventricular assist device (LVAD) implantation. SOPRANO was a phase 2, multicenter, double\u2010blind, randomized, placebo\u2010controlled, parallel\u2010group study. Patients with an LVAD implanted within the prior 90 days who had persistent PH (i.e., mean pulmonary arterial pressure \u226525\u2009mmHg, pulmonary artery wedge pressure [PAWP] \u226418\u2009mmHg, and pulmonary vascular resistance [PVR] &gt;3 Wood units [WU]) were randomized (1:1) to macitentan 10\u2009mg or placebo once daily for 12 weeks. The primary endpoint was change in PVR. Secondary endpoints included change in right\u2010heart catheterization hemodynamic variables, N\u2010terminal prohormone of brain natriuretic peptide levels, World Health Organization functional class, and safety\/tolerability. Fifty\u2010seven patients were randomized to macitentan (<jats:italic>n<\/jats:italic>\u2009=\u200928) or placebo (<jats:italic>n<\/jats:italic>\u2009=\u200929). A statistically significant reduction in PVR from baseline to Week 12 was observed with macitentan versus placebo (placebo\u2010corrected geometric mean ratio, 0.74; 95% confidence interval, 0.58\u20130.94; <jats:italic>p<\/jats:italic>\u2009=\u2009.0158). No statistically significant differences were observed in secondary endpoints. In a post\u2010hoc analysis, 66.7% of patients receiving macitentan achieved PVR\u2009&lt;3 WU versus 40.0% receiving placebo (<jats:italic>p<\/jats:italic>\u2009=\u2009.0383). Macitentan was generally well tolerated; adverse events were consistent with those in previous PAH studies with macitentan. In conclusion, macitentan showed promising tolerability and significantly reduced PVR in PH patients with persistently elevated PVR after LVAD implantation. ClinicalTrials. gov identifier: NCT02554903.<\/jats:p>","DOI":"10.1002\/pul2.12446","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T12:51:44Z","timestamp":1733316704000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["SOPRANO: Macitentan in patients with pulmonary hypertension following left ventricular assist device implantation"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4128-3978","authenticated-orcid":false,"given":"Robert P.","family":"Frantz","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Rochester Minnesota United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashank S.","family":"Desai","sequence":"additional","affiliation":[{"name":"Inova Fairfax Medical Center Falls Church Virginia United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Ewald","sequence":"additional","affiliation":[{"name":"Washington University St. Louis Missouri United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Franco","sequence":"additional","affiliation":[{"name":"Ohio State University Columbus Ohio United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Hage","sequence":"additional","affiliation":[{"name":"Cedars\u2010Sinai Medical Center Los Angeles California United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn M.","family":"Horn","sequence":"additional","affiliation":[{"name":"Weill Cornell Medical College New York New York United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shane J.","family":"LaRue","sequence":"additional","affiliation":[{"name":"Hannibal Clinic Hannibal Missouri United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Mathier","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Pittsburgh Pennsylvania United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacy","family":"Mandras","sequence":"additional","affiliation":[{"name":"AdventHealth Orlando Florida United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung H.","family":"Park","sequence":"additional","affiliation":[{"name":"Virginia Mason Franciscan Health Tacoma Washington United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashwin K.","family":"Ravichandran","sequence":"additional","affiliation":[{"name":"Ascension Medical Group Indianapolis Indiana United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3884-1994","authenticated-orcid":false,"given":"Joel D.","family":"Schilling","sequence":"additional","affiliation":[{"name":"Washington University St. Louis Missouri United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u2010wen","family":"Wang","sequence":"additional","affiliation":[{"name":"Memorial Healthcare System Hollywood Florida United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Zolty","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center Omaha Nebraska United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela Gomez","family":"Rendon","sequence":"additional","affiliation":[{"name":"Actelion Pharmaceuticals US, Inc. 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