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This study investigates whether inhibiting the conversion of dopamine into noradrenaline by dopamine <jats:italic>\u03b2<\/jats:italic>\u2010hydroxylase (D<jats:italic>\u03b2<\/jats:italic>H) inhibition with BIA 21\u20105337 improved right ventricular (RV) function or remodeling in pressure overload\u2010induced RV failure. RV failure was induced in male Wistar rats by pulmonary trunk banding (PTB). Two weeks after the procedure, PTB rats were randomized to vehicle (<jats:italic>n<\/jats:italic>\u2009=\u20098) or BIA 21\u20105337 (<jats:italic>n<\/jats:italic>\u2009=\u200911) treatment. An additional PTB group treated with ivabradine (<jats:italic>n<\/jats:italic>\u2009=\u200911) was included to control for the potential heart rate\u2010reducing effects of BIA 21\u20105337. A sham group (<jats:italic>n<\/jats:italic>\u2009=\u20096) received vehicle treatment. After 5 weeks of treatment, RV function was assessed by echocardiography, magnetic resonance imaging, and invasive pressure\u2013volume measurements before rats were euthanized. RV myocardium was analyzed to evaluate RV remodeling. PTB caused a fourfold increase in RV afterload which led to RV dysfunction, remodeling, and failure. Treatment with BIA 21\u20105337 reduced adrenal gland D<jats:italic>\u03b2<\/jats:italic>H activity and 24\u2010h urinary noradrenaline levels confirming relevant physiological response to the treatment. At end\u2010of\u2010study, there were no differences in RV function or RV remodeling between BIA 21\u20105337 and vehicle\u2010treated rats. In conclusion, treatment with BIA 21\u20105337 did not have any beneficial\u2014nor adverse\u2014effects on the development of RV failure after PTB despite reduced adrenal gland D<jats:italic>\u03b2<\/jats:italic>H activity.<\/jats:p>","DOI":"10.1002\/pul2.70008","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T12:32:01Z","timestamp":1731501121000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of dopamine \u03b2\u2010hydroxylase inhibition in pressure overload\u2010induced right ventricular failure"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7153-1170","authenticated-orcid":false,"given":"Stine","family":"Andersen","sequence":"first","affiliation":[{"name":"Department of Cardiology Aarhus University Hospital Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie S\u00f8rensen","family":"Axelsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Aarhus University Hospital Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders H.","family":"Nielsen\u2010Kudsk","sequence":"additional","affiliation":[{"name":"Department of Cardiology Aarhus University Hospital Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janne","family":"Schwab","sequence":"additional","affiliation":[{"name":"Department of Cardiology Aarhus University Hospital Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline D.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Aarhus University Hospital Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Ringgaard","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, MR Research Centre Aarhus University Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9102-3130","authenticated-orcid":false,"given":"Asger","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Aarhus University Hospital Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rowan","family":"Smal","sequence":"additional","affiliation":[{"name":"Department of Pulmonology Amsterdam University Medical Centre Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aida","family":"Lluci\u00e0\u2010Valldeperas","sequence":"additional","affiliation":[{"name":"Department of Pulmonology Amsterdam University Medical Centre Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frances","family":"Handoko de Man","sequence":"additional","affiliation":[{"name":"Department of Pulmonology Amsterdam University Medical Centre Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Igreja","sequence":"additional","affiliation":[{"name":"Department of Research BIAL, Portela &amp; C\u00aa, S.A. 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