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We therefore aimed to investigate regional distribution of RV MW and its correlation with catheter hemodynamics in children with PH. RV MW was calculated by longitudinal strain and simultaneous catheter pressure measurements in 14 patients with PH. Wasted MW was defined as the ratio of inappropriate myocardial lengthening to favorable shortening work. Segment\u2010wise and averaged MW and wasted MW were evaluated at baseline and during pulmonary vasodilation therapy with oxygen and nitric oxide, and their relationship to hemodynamic measurements was analyzed. We found that MW was higher for the lateral wall than the septum: 1013\u2009\u00b1\u2009374\u2009mmHg\u2009\u00b7\u2009% versus 532\u2009\u00b1\u2009190\u2009mmHg\u2009\u00b7\u2009% at baseline. Wasted MW ratio did not differ significantly between wall regions. Pulmonary vasodilators slightly reduced mean pulmonary artery pressure and was accompanied by a more symmetrical MW distribution. Averaged MW correlated with the rate of RV pressure development (dP\/dt maximum) and decay (dP\/dt minimum) at all conditions (<jats:italic>p\u2009<\/jats:italic>\u20090.047). The results suggest that MW contribute to, and may be used as a marker of, systolic and diastolic efficiency in the PH RV.<\/jats:p>","DOI":"10.1002\/pul2.70014","type":"journal-article","created":{"date-parts":[[2024,11,17]],"date-time":"2024-11-17T11:38:52Z","timestamp":1731843532000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Asymmetric right ventricular myocardial work correlates with gold standard measurements of cardiac function in pulmonary hypertension"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4977-3672","authenticated-orcid":false,"given":"Simone G.","family":"Diab","sequence":"first","affiliation":[{"name":"Department of Paediatric Cardiology Oslo University Hospital Oslo Norway"},{"name":"Institute of Clinical Medicine, Faculty of Medicine University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryota","family":"Ebata","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Graduate School of Medicine Chiba University Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dariusz","family":"Mroczek","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Labatt Family Heart Centre The Hospital for Sick Children Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Hui","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Labatt Family Heart Centre The Hospital for Sick Children Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Espen W.","family":"Remme","sequence":"additional","affiliation":[{"name":"Institute for Surgical Research Oslo University Hospital Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"M\u00f6ller","sequence":"additional","affiliation":[{"name":"Department of Paediatric Cardiology Oslo University Hospital Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark K.","family":"Friedberg","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Labatt Family Heart Centre The Hospital for Sick Children Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2019.06.022"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01916-2018"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1979.236.3.H498"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.113.000640"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.113.001071"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs016"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00191.2013"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jev078"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jew019"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2021.04.013"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015385.2023.2189870"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2022.04.058"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeaa261"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-023-03038-y"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2020.12.011"},{"key":"e_1_2_10_17_1","unstructured":"SamsethE. 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