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We performed a single\u2010center, retrospective, observational study of five patients with noninfectious complications of CVID. All patients had CVID as defined by the European Society of Immunodeficiencies criteria and had received intravenous immunoglobulin therapy. There were multiple pulmonary manifestations of CVID including frequent pneumonias, bronchiectasis, granulomatous lung disease, and pulmonary hypertension. All our patients were treated with pulmonary vasodilators for severe precapillary pulmonary hypertension along with individualized immunosuppression regimen for interstitial lung disease. Despite treatment for interstitial lung disease and PH, their conditions worsened over 2\u20133 years with all patients progressing toward organ transplant evaluation. Idiopathic thrombocytopenia and non\u2010cirrhotic portal hypertension were common, with three patients probably suffering from nodular regenerative hyperplasia. Noninfectious complications of CVID can affect different organs and progress despite advanced therapies. Single or multiorgan transplantation is a treatment option for patients with end\u2010stage organ involvement refractory to medical therapy.<\/jats:p>","DOI":"10.1002\/pul2.70034","type":"journal-article","created":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T09:18:36Z","timestamp":1735723116000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Common Variable Immunodeficiency Associated With Noninfectious Pulmonary Complications and Its Treatment: Beyond Immunoglobulin Therapy"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7295-7512","authenticated-orcid":false,"given":"Austin J.","family":"Parsons","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Henry Ford Hospital Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domingo","family":"Franco\u2010Palacios","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine, Henry Ford Hospital Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Kelly","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine, Henry Ford Hospital Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian","family":"Grafton","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Henry Ford Hospital Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javardo","family":"McIntosh","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine, Henry Ford Hospital Detroit Michigan 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