{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T16:38:29Z","timestamp":1770741509607,"version":"3.49.0"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013342","name":"NIHR Imperial Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013342","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pulm. circ."],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Pulmonary arteriovenous malformations (PAVMs) cause cerebral abscess and ischemic stroke due to paradoxical emboli, risks that are increasingly recognized. We report the evolving placement of thoracic surgery in multi\u2010disciplinary team management of PAVMs that were sporadic or associated with hereditary hemorrhagic telangiectasia. From 1983 to 2006, all patients receiving elective treatment had embolization. Between January 2006 and July 2022, 24 of 714 (3%) patients reviewed at our institution underwent elective surgical resection of one or more PAVMs. Initially, the bar for elective surgery had been set very high, and only patients with persistent symptoms of cerebral ischemia after maximal embolization and medical therapy were referred. As PAVM natural history, follow\u2010up radiation exposures for residual PAVMs, and good surgical outcomes were appreciated, PAVM resection became part of the discussion for highly localized, very complex PAVMs which we consider are best treated surgically. Elective surgical intervention may be considered for other selected patients.<\/jats:p>","DOI":"10.1002\/pul2.70037","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T08:40:19Z","timestamp":1736239219000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Elective Thoracic Surgical Resections for Pulmonary Arteriovenous Malformations \u2010 A 16 Year Single\u2010Center Experience"],"prefix":"10.1002","volume":"15","author":[{"given":"May","family":"Al\u2010Sahaf","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery Hammersmith Hospital, Imperial College Healthcare NHS Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Hammersmith Hospital, Imperial College Healthcare NHS Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2220-338X","authenticated-orcid":false,"given":"Jayanta","family":"Nandi","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Hammersmith Hospital, Imperial College Healthcare NHS Trust London UK"},{"name":"National Heart and Lung Institute, Imperial College London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6688-8637","authenticated-orcid":false,"given":"Ali","family":"Alsafi","sequence":"additional","affiliation":[{"name":"Department of Imaging Imperial College Healthcare NHS Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9007-5775","authenticated-orcid":false,"given":"Claire L.","family":"Shovlin","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London UK"},{"name":"Respiratory Medicine Imperial College Healthcare NHS Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","unstructured":"R.Hermann C. L.Shovlin R. S.Kasthuri et al. \u201cHereditary Haemorrhagic Telangiectasia \u201dNature Reviews Disease Primers(2025) https:\/\/doi.org\/10.1038\/s41572-024-00585-z.","DOI":"10.1038\/s41572-024-00585-z"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.7326\/M20-1443"},{"key":"e_1_2_8_4_1","unstructured":"A.AlsafiandC. L.Shovlin Orphanet Definition of Pulmonary Arteriovenous Malformation accessed 16 September 2024 https:\/\/www.orpha.net\/en\/disease\/detail\/2038."},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carj.2013.02.007"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2017-210764"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix373"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000013169"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.032073"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(93)91156-H"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2021-218332"}],"container-title":["Pulmonary Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pul2.70037","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T10:33:46Z","timestamp":1744367626000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pul2.70037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/pul2.70037"],"URL":"https:\/\/doi.org\/10.1002\/pul2.70037","archive":["Portico"],"relation":{},"ISSN":["2045-8940","2045-8940"],"issn-type":[{"value":"2045-8940","type":"print"},{"value":"2045-8940","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-05-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70037"}}