{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:04:58Z","timestamp":1785150298466,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"vor","delay-in-days":55,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pulm. circ."],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>There is a need for objective, continuous and remote assessment of exercise capacity in patients with pulmonary arterial hypertension (PAH). Using data from the TRACE study, in which 108 adult patients with PAH were continuously monitored with a wrist\u2010worn accelerometer, we evaluated whether actigraphy can facilitate continuous monitoring of exercise capacity. Distributions of step rate, distance and duration of patient's walking bouts were estimated at baseline, Week 16 and Week 24 using 2\u2010week periods of actigraphy data. Twenty\u2010one metrics per walking bout characteristic were described (mean, standard deviation, 19 percentiles [5th\u201395th]). The relationships between these metrics and the 6\u2010min walk distance (6MWD), Borg dyspnea index (BDI), and the PAH Symptoms and Impact questionnaire (PAH\u2010SYMPACT) Physical Impact domain score were assessed at the three timepoints. Test\u2010retest reliability, and discriminant and known\u2010group validity of each metric were also evaluated. All metrics of step rate and bout distance were significantly correlated with 6MWD (Pearson's correlation coefficients: 0.34\u20130.67; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.005) and the PAH\u2010SYMPACT Physical Impact domain score (Pearson's correlation coefficients:\u2009\u22120.51 to\u2009\u22120.32; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) at all timepoints. Negative correlations were also observed with the BDI and the actigraphy\u2010derived metrics, with the majority reaching significance. Strong test\u2010retest reliability was demonstrated (intra\u2010class correlation coefficient \u2265\u20090.70). The metrics differentiated well between patients with varying disease severity levels. In conclusion, actigraphy\u2010derived metrics of patients' walking bouts correlate significantly with 6MWD, BDI and physical impacts of PAH, indicating the utility of actigraphy in facilitating continuous monitoring of exercise capacity in adult patients with PAH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link>: NCT03078907; URL: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">clinicaltrials.gov<\/jats:ext-link>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pul2.70097","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T04:19:24Z","timestamp":1748319564000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Characteristics of Daily Walking Bouts as Valid and Reliable Indicators of Exercise Capacity in Pulmonary Arterial Hypertension: Insights From the Randomized Controlled Study With Selexipag (TRACE)"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4885-7455","authenticated-orcid":false,"given":"Rana Zia Ur","family":"Rehman","sequence":"first","affiliation":[{"name":"Janssen Pharmaceutical Companies of Johnson &amp; Johnson High Wycombe Buckinghamshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2111-6024","authenticated-orcid":false,"given":"Federico","family":"Parisi","sequence":"additional","affiliation":[{"name":"Janssen Pharmaceutical Companies of Johnson &amp; Johnson Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noman","family":"Ashraf","sequence":"additional","affiliation":[{"name":"Janssen Pharmaceutical Companies of Johnson &amp; Johnson Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4548-8962","authenticated-orcid":false,"given":"Meenakshi","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Janssen Pharmaceutical Companies of Johnson &amp; Johnson Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4128-3978","authenticated-orcid":false,"given":"Robert P.","family":"Frantz","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2755-5845","authenticated-orcid":false,"given":"Anna R.","family":"Hemnes","sequence":"additional","affiliation":[{"name":"Division of Allergy, Pulmonary and Critical Care Medicine Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9037-1400","authenticated-orcid":false,"given":"Nikolay V.","family":"Manyakov","sequence":"additional","affiliation":[{"name":"Janssen Pharmaceutical Companies of Johnson &amp; 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