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The vasculature that expands and supplies lung cancers is better described, with the recent recognition that systemic bronchial circulation expands to be the main blood supply to primary lung tumors. Here, we use publicly available single\u2010cell RNA\u2010sequencing (scRNA\u2010seq) data to compare vascular endothelial cell (EC) populations in multiple progressive interstitial lung diseases (ILD) and non\u2010small cell lung cancer (NSCLC) to identify common and distinct features. Lung tissue specimens were collected from healthy lung tissue (<jats:italic>n\u2009<\/jats:italic>=\u200959), ILD (<jats:italic>n\u2009<\/jats:italic>=\u200997), chronic obstructive pulmonary disease (<jats:italic>n\u2009<\/jats:italic>=\u200922), and NSCLC (<jats:italic>n\u2009<\/jats:italic>=\u20098). We identify two subtypes of expanded EC populations in both ILD and NSCLC, \u201cBronch\u20101\u201d and \u201cBronch\u20102\u201d, expressing transcripts associated with venules and angiogenic tip\/stalk cells, respectively. Relative to pulmonary capillary and arterial ECs, bronchial ECs show low expression of transcripts associated with vascular barrier integrity. The pan\u2010bronchial EC marker COL15A1 showed positive staining in lung parenchyma from patients with IPF, SSc\u2010ILD, and NSCLC, whereas positive staining was limited to subpleural and peri\u2010bronchial regions in non\u2010fibrotic controls. In conclusion, expansion of a subset of ECs expressing markers of the bronchial circulation is one of the most pronounced changes in vascular cell composition across multiple ILDs and NSCLC. These data support additional studies to determine the role of the bronchial vasculature in ILD progression.<\/jats:p>","DOI":"10.1002\/pul2.70102","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T07:19:13Z","timestamp":1748935153000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Ectopic Expansion of Pulmonary Vasculature in Fibrotic Lung Disease and Lung Adenocarcinoma Marked by Proangiogenic COL15A1+ Endothelial Cells"],"prefix":"10.1002","volume":"15","author":[{"given":"Eric","family":"Engelbrecht","sequence":"first","affiliation":[{"name":"University of Louisville School of Medicine Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tristan","family":"Kooistra","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital Harvard Medical School Boston Massachusetts 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