{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T15:15:25Z","timestamp":1778944525271,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T00:00:00Z","timestamp":1759017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pulm. circ."],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Identifying noninvasive measures to assess intravascular volume status and risk stratify patients with pulmonary hypertension (PH) and chronic kidney disease (CKD) is needed. We assessed the predictive value of estimated plasma volume status (ePVS) using the Strauss\u2010derived Duarte formula in PH\u2013CKD patients. This single\u2010center retrospective cohort analysis included patients with PH and CKD Stage 3b (CKD3b), Stage 4 (CKD4), or Stage 5 (CKD5) who underwent right heart catheterization from 2018 to 2023. Patients were categorized into low ePVS (&lt;\u20096.2) and high ePVS (\u2265\u20096.2) using Youden's\n                    <jats:italic>J<\/jats:italic>\n                    statistics. We used the Cox\u2010proportional hazards model, adjusting for age, sex, and body mass index, to investigate the association between high ePVS and major adverse cardiovascular events (MACE) and all\u2010cause mortality within 1 year after ePVS measurement date. Of 305 patients with PH\u2013CKD, 30% (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200991) had low ePVS, and 70% (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009215) had high ePVS. Compared to the low ePVS group, patients with high ePVS had higher left ventricular ejection fraction, right atrial pressure, pulmonary artery wedge pressure, and cardiac index, lower pulmonary vascular resistance, worse kidney function, and more chronic anemia. Among patients with precapillary or Cpc\u2010PH, high ePVS was associated with a greater incidence of 1\u2010year all\u2010cause mortality (adjusted HR\u2009=\u20092.11, 95% CI 1.06\u20134.22\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.034). Among PH\u2013CKD patients, high ePVS was associated with hyperdynamic circulation, worse kidney function, and anemia. High ePVS was associated with greater 1\u2010year all\u2010cause mortality among patients with a precapillary PH component.\n                  <\/jats:p>","DOI":"10.1002\/pul2.70157","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T10:29:18Z","timestamp":1759141758000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association of Estimated Plasma Volume Status With Invasive Hemodynamics and Adverse Clinical Outcomes in Patients With Pulmonary Hypertension and Chronic Kidney Disease"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3835-7359","authenticated-orcid":false,"given":"Andrew","family":"Geller","sequence":"first","affiliation":[{"name":"Department of Medicine Jefferson Einstein Philadelphia Hospital Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Manuel","family":"Martinez Manzano","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Division of Pulmonary and Critical Care Medicine Brigham and Women's Hospital Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esteban","family":"Kosak Lopez","sequence":"additional","affiliation":[{"name":"Department of Medicine Jefferson Einstein Philadelphia Hospital Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0086-5269","authenticated-orcid":false,"given":"Phuuwadith","family":"Wattanachayakul","sequence":"additional","affiliation":[{"name":"Department of Medicine Jefferson Einstein Philadelphia Hospital Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Malin","sequence":"additional","affiliation":[{"name":"Department of Medicine Jefferson Einstein Philadelphia Hospital Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9125-4632","authenticated-orcid":false,"given":"Raul","family":"Leguizamon","sequence":"additional","affiliation":[{"name":"Department of Medicine Jefferson Einstein Philadelphia Hospital Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tara A.","family":"John","sequence":"additional","affiliation":[{"name":"Department of Medicine Jefferson Einstein Philadelphia Hospital Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasha","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Medicine Jefferson Einstein Philadelphia Hospital Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"McLaren","sequence":"additional","affiliation":[{"name":"Department of Medicine Jefferson Einstein Philadelphia Hospital Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Prendergast","sequence":"additional","affiliation":[{"name":"Department of Medicine Jefferson Einstein Philadelphia Hospital Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone A.","family":"Jarrett","sequence":"additional","affiliation":[{"name":"NYU Grossman School of Medicine, Division of Gastroenterology and Hepatology New York University Langone Health New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin Bryan","family":"Lo","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Division of Cardiovascular Medicine Brigham and Women's Hospital Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Witzke","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sidney Kimmel Medical College, Jefferson Einstein Philadelphia Hospital Thomas Jefferson University Philadelphia Pennsylvania 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