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We present the case of a 10\u2010year\u2010old male with recurrent adhesive\u2010related skin reactions, which compromised both subcutaneous and intravenous continuous treatment. Due to comorbid atopic dermatitis (AD), dupilumab was initiated to decrease skin reactions to adhesives. Within 48\u2009h of initiation, skin reactions completely resolved. With sustained dupilumab treatment, he remains symptom\u2010free and is successfully tolerating intravenous treprostinil infusion.<\/jats:p>","DOI":"10.1002\/pul2.70158","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T07:37:30Z","timestamp":1757662650000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Use of Dupilumab to Treat Cutaneous Complications of Continuous Prostacyclin Infusion in Pulmonary Hypertension: A Case Report and Review of Literature"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4422-3065","authenticated-orcid":false,"given":"Nidhy P.","family":"Varghese","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Pulmonology Baylor College of Medicine Houston Texas USA"},{"name":"Texas Children's Hospital Pulmonary Hypertension Center at the Texas Medical Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin","family":"Ely","sequence":"additional","affiliation":[{"name":"Texas Children's Hospital Pulmonary Hypertension Center at the Texas Medical Center Houston Texas USA"},{"name":"Department of Nursing Texas Children's Hospital Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rozmeen","family":"Fombin","sequence":"additional","affiliation":[{"name":"Texas Children's Hospital Pulmonary Hypertension Center at the Texas Medical Center Houston Texas USA"},{"name":"Department of Nursing Texas Children's Hospital Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Champion","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pulmonology Baylor College of Medicine Houston Texas USA"},{"name":"Texas Children's Hospital Pulmonary Hypertension Center at the Texas Medical Center Houston Texas USA"},{"name":"Advanced Practice Providers Texas Children's Hospital Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6191-8881","authenticated-orcid":false,"given":"Elise","family":"Whalen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pulmonology Baylor College of Medicine Houston Texas USA"},{"name":"Texas Children's Hospital Pulmonary Hypertension Center at the Texas Medical Center Houston Texas USA"},{"name":"Advanced Practice Providers Texas Children's Hospital Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pul2.12224"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2020.101049"},{"key":"e_1_2_9_4_1","unstructured":"3M. 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Published online November 2020 accessed June 10 2025 https:\/\/www.smith-nephew.com\/en-gb\/health-care-professionals\/products\/advanced-wound-management\/iv3000-global-only#evidenceandcasestudies."},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-025-09057-y"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2024.08.001"},{"key":"e_1_2_9_8_1","unstructured":"Dupixent\u00ae (dupilumab) Data at Revolutionizing Atopic Dermatitis (RAD) Conference Reinforce Use in Atopic Dermatitis Patients with Skin of Color | Regeneron Pharmaceuticals Inc accessed June 10 2025 https:\/\/investor.regeneron.com\/news-releases\/news-release-details\/dupixentr-dupilumab-data-revolutionizing-atopic-dermatitis-rad."},{"key":"e_1_2_9_9_1","unstructured":"Dupilumab Monotherapy Improves AD Severity and Pigmentation in People With Skin of Color accessed June 10 2025 https:\/\/www.patientcareonline.com\/view\/dupilumab-monotherapy-improves-ad-severity-and-pigmentation-in-patients-with-skin-of-color."},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/life12101670"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01345-2024"}],"container-title":["Pulmonary Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pul2.70158","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T05:48:48Z","timestamp":1758865728000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pul2.70158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/pul2.70158"],"URL":"https:\/\/doi.org\/10.1002\/pul2.70158","archive":["Portico"],"relation":{},"ISSN":["2045-8940","2045-8940"],"issn-type":[{"type":"print","value":"2045-8940"},{"type":"electronic","value":"2045-8940"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2025-06-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70158"}}