{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T07:03:12Z","timestamp":1775890992728,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pulm. circ."],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Early graft dysfunction following lung transplantation is commonly attributed to primary graft dysfunction (PGD). However, other rare etiologies may present with similar clinical and radiologic features. We report a unique case of a 58\u2010year\u2010old male with idiopathic pulmonary fibrosis who underwent bilateral lung transplantation. The donor was a young adult with traumatic brain injury. Within hours post\u2010transplant, the recipient developed severe hypoxemia and diffuse infiltrates on chest imaging, consistent with Grade 3 PGD. Despite supportive therapy, there was limited improvement. Histopathological examination of transbronchial biopsies revealed cerebral cortical neurons and glial tissue embedded in the pulmonary vasculature, confirming cerebral tissue embolism. This case highlights cerebral tissue pulmonary embolism as an under\u2010recognized cause of early allograft dysfunction. Clinicians should consider donor\u2010derived embolic events, particularly in trauma\u2010related donors, in the differential diagnosis of PGD\u2010like presentations.<\/jats:p>","DOI":"10.1002\/pul2.70237","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T18:14:20Z","timestamp":1768241660000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cerebral Tissue Pulmonary Embolism Masquerading as Primary Graft Dysfunction After Lung Transplantation"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1150-1057","authenticated-orcid":false,"given":"Shimon","family":"Izhakian","sequence":"first","affiliation":[{"name":"Pulmonary Institute Beilinson Hospital, Rabin Medical Center Petah Tikva Israel"},{"name":"Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moshe","family":"Heching","sequence":"additional","affiliation":[{"name":"Pulmonary Institute Beilinson Hospital, Rabin Medical Center Petah Tikva Israel"},{"name":"Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludmila","family":"Fridel","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Pathology Institute Rabin Medical Center Petah Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dror","family":"Rosengarten","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Pathology Institute Rabin Medical Center Petah Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mordechai R.","family":"Kramer","sequence":"additional","affiliation":[{"name":"Pulmonary Institute Beilinson Hospital, Rabin Medical Center Petah Tikva Israel"},{"name":"Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osnat","family":"Shtraichman","sequence":"additional","affiliation":[{"name":"Pulmonary Institute Beilinson Hospital, Rabin Medical Center Petah Tikva Israel"},{"name":"Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2017.07.021"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02389.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAF.0000000000000612"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1520\/JFS13638J"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0044-1782536"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezv347"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2005.07.025"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.13407"},{"issue":"1","key":"e_1_2_9_10_1","first-page":"72","article-title":"Donor Cerebral Emboli as a Cause of Acute Graft Dysfunction in Lung Transplantation","volume":"11","author":"Rosendale B. 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