{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:36:41Z","timestamp":1792521401757,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T00:00:00Z","timestamp":1768694400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pulm. circ."],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Pulmonary hypertension (PH) associated with left heart disease (LHD\u2010PH) and pulmonary hypertension associated with chronic lung disease (CLD\u2010PH) are the most common PH subtypes but lack effective treatments. In a prospective cohort study, 90 patients (39 LHD\u2010PH, 51 CLD\u2010PH) with severe disease [pulmonary vascular resistance (PVR)\u2009&gt;\u20095 Wood units and recent right heart failure (RHF)] were treated with subcutaneous Treprostinil (scTRE). Clinical, echocardiographic, and hemodynamic parameters were assessed at baseline and at 12 months; survival was tracked for 5 years. In LHD\u2010PH and CLD\u2010PH patients at 12 months, 6\u2010min walking distance (6MWD) improved by 88\u2009m [64;112] and 52\u2009m [22;89], respectively, World Health Organisation functional class (WHO FC) improved in 77% and 78% of patients and mean pulmonary artery pressure (mPAP) decreased by 5.78\u2009mmHg and 9.05\u2009mmHg, respectively. Tricuspid annular plane systolic excursion\/systolic pulmonary artery pressure (TAPSE\/sPAP) ratio improved in patients with CLD\u2010PH. Median scTRE dose at 12 months was 30\u2009ng\/kg\/min. Overall survival at 5 years was 38.6% in LHD\u2010PH group and 49.7% in CLD\u2010PH group. Patients with baseline pulmonary arterial wedge pressure (PAWP)\u2009&lt;\u200912\u2009mmHg had better outcomes. Open\u2010label scTRE was associated with a spectrum of clinically relevant benefits in a select group of LHD\u2010PH and CLD\u2010PH patients recently hospitalized for RV failure and was well tolerated.<\/jats:p>","DOI":"10.1002\/pul2.70241","type":"journal-article","created":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T15:29:35Z","timestamp":1768750175000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Subcutaneous Treprostinil in PH Associated With Left Heart Disease or Chronic Lung Disease"],"prefix":"10.1002","volume":"16","author":[{"given":"Roela","family":"Sadushi\u2010Koli\u00e7i","sequence":"first","affiliation":[{"name":"Department of Internal Medicine II, Division of Cardiology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3646-8379","authenticated-orcid":false,"given":"Leila","family":"Alajbegovic","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, Division of Cardiology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Gojic","sequence":"additional","affiliation":[{"name":"AOP\u2010Health Pharmaceuticals GmbH  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nika","family":"Skoro\u2010Sajer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, Division of Cardiology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioana","family":"Campean","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, Division of Cardiology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inbal","family":"Shafran","sequence":"additional","affiliation":[{"name":"Pulmonary Institute, Sheba Medical Center, Tel HaShomer, Ramat Gan, Israel; Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deddo","family":"M\u00f6rtl","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I Division of Cardiology, University Hospital of St P\u00f6lten  St P\u00f6lten Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6777-0996","authenticated-orcid":false,"given":"Christian","family":"Gerges","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, Division of Cardiology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0485-2692","authenticated-orcid":false,"given":"Irene M.","family":"Lang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, Division of Cardiology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac237"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(15)00543-3"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv512"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30317-9"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx700"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0199164"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2019.07.028"},{"issue":"7","key":"e_1_2_9_9_1","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.114.002358","article-title":"Effect of Pulmonary Hypertension Hemodynamic Presentation on Clinical Outcomes in Patients With Severe Symptomatic Aortic Valve Stenosis Undergoing Transcatheter Aortic Valve Implantation: Insights From the New Proposed Pulmonary Hypertension Classification","volume":"8","author":"O'Sullivan C. 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