{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:07:52Z","timestamp":1790647672719,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pulm. circ."],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Pulmonary hypertension (PH) causes progressive pulmonary vascular resistance and right heart failure. We investigated whether beta\u2010alanine (\u03b2\u2010Ala) improves right ventricular (RV) remodeling and dysfunction in a monocrotaline (MCT)\u2010induced PH rat model. Male Wistar rats were assigned to control, MCT\u2010PH, and \u03b2\u2010Ala\u2010treated PH groups. RV function was assessed by RVSP and RVHI; molecular changes were examined by western blotting and qPCR; histology evaluated RV hypertrophy and fibrosis. \u03b2\u2010Ala significantly improved RVSP and RVHI versus MCT. Mechanistically, \u03b2\u2010Ala reduced ERK and p38 MAPK signaling while enhancing AKT activation. It decreased proapoptotic Bax and cleaved Caspase\u20103 and increased antiapoptotic Bcl\u20102. qPCR showed downregulation of ANP, BNP, \u03b2\u2010MHC, and TGF\u2010\u03b2, with upregulation of \u03b2\u2010MHC. Histological analyses confirmed attenuation of RV hypertrophy and fibrosis. Overall, \u03b2\u2010Ala mitigates RV remodeling and dysfunction in MCT\u2010induced PH, likely via modulation of MAPK\/AKT pathways and apoptosis, supporting its potential as a therapy for PH\u2010related right heart dysfunction.<\/jats:p>","DOI":"10.1002\/pul2.70244","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T12:33:49Z","timestamp":1769171629000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Beta\u2010Alanine Supplementation Ameliorates Right Ventricular Remodeling Caused by Monocrotaline\u2010Induced Pulmonary Hypertension"],"prefix":"10.1002","volume":"16","author":[{"given":"Hongling","family":"Su","sequence":"first","affiliation":[{"name":"The First Clinical Medical College of Lanzhou University  Lanzhou P. R. China"},{"name":"Department of Cardiology, Pulmonary Vascular Disease Center (PVDC) Gansu Provincial Hospital  Lanzhou P. R. 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