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TMEM100 permitted the TGF\u03b21\u2010induced increase of ALK1, while repressing ALK5, and preventing ALK1\u2013TMEM100 signaling impaired angiogenesis ex vivo. Our data indicate that TGF\u03b21\u2013ALK1\u2013TMEM100 signaling is active during CTEPH thrombus revascularization.<\/jats:p>","DOI":"10.1002\/pul2.70253","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T05:36:26Z","timestamp":1769664986000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Transmembrane Protein 100 Expression on Endothelial Cells Vascularizing Thrombi in Chronic Thromboembolic Pulmonary Hypertension Modulates TGF\u03b21\u2212ALK1 Signaling During Angiogenesis"],"prefix":"10.1002","volume":"16","author":[{"given":"Magdalena L.","family":"Bochenek","sequence":"first","affiliation":[{"name":"Department of Cardiology, Cardiology I University Medical Center Mainz Mainz Germany"},{"name":"Center for Thrombosis and Hemostasis, University Medical Center Mainz Mainz Germany"},{"name":"German Center for Cardiovascular Research, Partner Site RhineMain Mainz 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