{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T05:17:14Z","timestamp":1783574234566,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pulm. circ."],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Use of subcutaneous treprostinil (TRE) in children with pulmonary hypertension (PH) secondary to lung disease (group 3 PH) is not well described. We hypothesized that initiation of TRE is associated with improvement in PH severity and right ventricular (RV) function with minimal early side effects. We conducted a single\u2010center retrospective analysis of children with group 3 PH treated with TRE between 2006 and 2022. We compared echocardiographic changes in PH severity and RV systolic function over the first 3\u20106 months of TRE and described adverse effects over the first 48\u2009h of therapy. Forty\u2010one patients (56% male), aged 6 days to 15 years old at the time of TRE initiation, were included. The most common associated diagnoses were bronchopulmonary dysplasia (63%), congenital diaphragmatic hernia (10%), and pulmonary hypoplasia (10%). TRE was associated with improvement in PH severity (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), estimated by interventricular septal position at end\u2010systole (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001), RV systolic pressure to systemic blood pressure ratio (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), and flow direction across a simple shunt (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.153). There were improvements in individual markers of RV function including tricuspid annular plane systolic excursion (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.005), tricuspid annulus dilation (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.004), RV global longitudinal strain (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), RV free wall longitudinal strain (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), and qualitative RV systolic function (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002). Over the first 48\u2009h of TRE, the dose was reduced in 3 patients (7%) due to hypotension, hypoxemia, or emesis, all of whom tolerated re\u2010escalation within 48\u2009h. TRE is well tolerated and is associated with early improvement in PH severity and RV function in children with group 3 PH.\n                  <\/jats:p>","DOI":"10.1002\/pul2.70304","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T11:43:02Z","timestamp":1777030982000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Treprostinil Is Associated With Early and Sustained Improvement in Group 3 Pulmonary Hypertension and Right Ventricular Function in Children"],"prefix":"10.1002","volume":"16","author":[{"given":"Kaushik","family":"Parvathaneni","sequence":"first","affiliation":[{"name":"Divison of Cardiology, Department of Pediatrics Stanford University School of Medicine Palo Alto CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5952-3493","authenticated-orcid":false,"given":"Justin J.","family":"Kochanski","sequence":"additional","affiliation":[{"name":"Divison of Cardiology, Department of Pediatrics Stanford University School of Medicine Palo Alto CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megha D.","family":"Tandel","sequence":"additional","affiliation":[{"name":"Quantitative Sciences Unit, Department of Medicine Stanford University Palo Alto CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Liu","sequence":"additional","affiliation":[{"name":"Divison of Cardiology, Department of Pediatrics Stanford University School of Medicine Palo Alto CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisa","family":"Arunamata","sequence":"additional","affiliation":[{"name":"Divison of Cardiology, Department of Pediatrics Stanford University School of Medicine Palo Alto CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A.","family":"Feinstein","sequence":"additional","affiliation":[{"name":"Divison of Cardiology, Department of Pediatrics Stanford University School of Medicine Palo Alto CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel K.","family":"Hopper","sequence":"additional","affiliation":[{"name":"Divison of Cardiology, Department of Pediatrics Stanford University School of Medicine Palo Alto CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2013.01.1055"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2018.03.067"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.09.025"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/2045894018759247"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2023.11.004"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.04.052"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2023.113420"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.06.016"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2017.03.058"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-2330"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.09.119"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.13106"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-023-03282-y"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1086\/674762"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/pul2.12224"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/pul2.12104"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2014.00124"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2013.06.022"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(85)90157-2"},{"key":"e_1_2_10_21_1","unstructured":"BCH Z\u2010Score Calculator. 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