{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T05:17:06Z","timestamp":1783574226826,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":50,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pulm. circ."],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Sotatercept has recently expanded treatment options for pulmonary arterial hypertension (PAH), but its mental health and quality\u2010of\u2010life impact is not well characterized. We assessed psychiatric diagnoses and patient\u2010reported outcomes in PAH patients treated with sotatercept within the clinical trial program. PAH Patients previously assessed for psychiatric disorders and quality of life were re\u2010evaluated after \u2265\u20096 months of sotatercept exposure. A senior psychiatrist performed a Structured Clinical Interview for DSM\u20105, and participants completed validated questionnaires assessing anxiety\/depression (HADS), metacognitive beliefs (MCQ\u201030), quality of life (WHOQOL\u2010BREF), and PAH\u2010related symptoms\/impacts (PAH\u2010SYMPACT\u2122), alongside items capturing patient experiences during therapy. Twenty patients (85% female; median age 46 years) were included. Hemodynamics, biomarkers, and 6\u2010min walk distance improved. The prevalence of at least one current psychiatric disorder remained high and largely unchanged from baseline to follow\u2010up (50% to 45%). Major depressive disorder remained stable (25%), whereas adjustment disorder newly occurred in 25% of patients. HADS and MCQ\u201030 scores did not change. WHOQOL\u2010BREF global scores increased modestly, but the mental health domain declined substantially (69.6\u2009\u00b1\u200913.3 to 48.1\u2009\u00b1\u200915.5,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001). PAH\u2010SYMPACT\u2122 indicated low symptom burden at follow\u2010up. Many patients reported increased optimism and plans to travel or return to work, while some expressed concerns about finances and social security. While sotatercept treatment led to clinical improvements in PAH patients, the prevalence of mental disorders remained high with an increased prevalence in adjustment disorder. These findings support routine mental health assessment and targeted psychosocial support when initiating life\u2010changing PAH therapies.\n                  <\/jats:p>","DOI":"10.1002\/pul2.70324","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T10:21:47Z","timestamp":1779358907000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mental Disorders and Quality of Life in Patients With Pulmonary Arterial Hypertension Treated With Sotatercept"],"prefix":"10.1002","volume":"16","author":[{"given":"Jan","family":"Fuge","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine and Infectious Diseases Hannover Medical School Hannover Germany"},{"name":"Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL) Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5302-1548","authenticated-orcid":false,"given":"Karen M.","family":"Olsson","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Infectious Diseases Hannover Medical School Hannover Germany"},{"name":"Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL) Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kira","family":"Remmert","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Infectious Diseases Hannover Medical School Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britta","family":"Stapel","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Social Psychiatry and Psychotherapy Hannover Medical School Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5002-409X","authenticated-orcid":false,"given":"Jan C.","family":"Kamp","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Infectious Diseases Hannover Medical School Hannover Germany"},{"name":"Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL) Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0902-4773","authenticated-orcid":false,"given":"Da\u2010Hee","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Infectious Diseases Hannover Medical School Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius M.","family":"Hoeper","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Infectious Diseases Hannover Medical School Hannover Germany"},{"name":"Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL) Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lotta","family":"Winter","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Social Psychiatry and Psychotherapy Hannover Medical School Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai G.","family":"Kahl","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Social Psychiatry and Psychotherapy Hannover Medical School Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"e_1_2_12_2_1","first-page":"3618","article-title":"2022 ESC\/ERS Guidelines for the Diagnosis and Treatment of Pulmonary Hypertension","volume":"43","author":"Humbert 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