{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:58:49Z","timestamp":1790841529613,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF20OC0064556"],"award-info":[{"award-number":["NNF20OC0064556"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pulm. circ."],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Pulmonary hypertension (PH) is a condition characterized by elevated mean pulmonary arterial pressure confirmed by right heart catheterization. PH involves both structural and functional changes in the pulmonary vascular bed. Since 2022, a four\u2010level risk stratification has been used to predict 1\u2010year mortality at follow\u2010up. This system is based on the World Health Organization Functional Classification (WHO\u2010FC), 6\u2010min walk distance, and the pro\u2010Brain Natriuretic Peptide level combined.<\/jats:p>\n                  <jats:p>This study included 47 patients with suspected PH. Of these, 40 were diagnosed with PH while 7 was not, and 6 were included as similarly presenting controls. Untargeted metabolomics using ultra\u2010high pressure liquid chromatography mass spectrometry (UHPLC\u2010MS), and gas chromatography mass spectrometry (GC\u2010MS) showed correlations with both risk strata and their component measurements: N\u2010terminal pro\u2010brain natriuretic peptide (NT\u2010proBNP), World Health Organization Functional Class (WHO\u2010FC), and the 6\u2010min walk distance (6MWD). There was a greater overlap in metabolites associated with WHO\u2010FC or 6MWD than between either of them and NT\u2010proBNP. Several of these metabolites showed the same pattern in a verification data set of 35 PH patients.<\/jats:p>\n                  <jats:p>In conclusion, metabolic patterns in pulmonary hypertension (PH) are related to the predicted risk of disease progression. The clinical variables that contribute to prognostic stratification have overlapping but distinct metabolic associations. Further research is needed to verify how these patterns relate to disease progression in a longitudinal cohort. Metabolomics provides a potential new tool for defining risk in PH.<\/jats:p>","DOI":"10.1002\/pul2.70342","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T11:22:03Z","timestamp":1784114523000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Metabolic Markers as Potential Risk Factors in Pulmonary Hypertension"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2878-6194","authenticated-orcid":false,"given":"Sarah","family":"McGarrity","sequence":"first","affiliation":[{"name":"CAG Center for Endotheliomics Copenhagen University Hospital \u2010 Rigshospitalet Copenhagen Denmark"},{"name":"Department of Clinical Immunology Copenhagen University Hospital \u2010 Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9778-5964","authenticated-orcid":false,"given":"P\u00e4r I","family":"Johansson","sequence":"additional","affiliation":[{"name":"CAG Center for Endotheliomics Copenhagen University Hospital \u2010 Rigshospitalet Copenhagen Denmark"},{"name":"Department of Clinical Immunology Copenhagen University Hospital \u2010 Rigshospitalet Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rn","family":"Carlsen","sequence":"additional","affiliation":[{"name":"CAG Center for Endotheliomics Copenhagen University Hospital \u2010 Rigshospitalet Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen Copenhagen Denmark"},{"name":"Department of Cardiology Copenhagen University Hospital \u2010 Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv317"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00879-2022"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01913-2018"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2019.02.004"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.70155"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2022.2108684"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241713227"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2021.166200"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3MO00266G"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-17374-x"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.03201-2020"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-76514-7"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.3c00255"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-021-01845-9"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo12090845"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.311737"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.42632"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2024.1341145"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2024.1387195"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.122.321923"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/2045894019890553"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo12090845"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2023.107157"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.018349"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.024602"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.122.321923"},{"key":"e_1_2_13_28_1","unstructured":"UPLC\/MS Monitoring of Water\u2010Soluble Vitamin Bs in Cell Culture Media in Minutes [Internet]. cited 2025 Jul 2 https:\/\/www.waters.com\/nextgen\/dk\/en\/library\/application-notes\/2011\/uplc-ms-monitoring-water-soluble-vitamin-bs-cell-culture-media-minutes.html."},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.21105\/joss.01686"},{"key":"e_1_2_13_30_1","unstructured":"Pipe\u2010Friendly Framework for Basic Statistical Tests. cited 2025 Jul 2 https:\/\/rpkgs.datanovia.com\/rstatix\/."},{"key":"e_1_2_13_31_1","unstructured":"K.Yoshida A.Bartel J. 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