{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T16:32:32Z","timestamp":1793032352096,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":51,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pulm. circ."],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Right heart catheterization (RHC) and echocardiography are integral in the assessment of pulmonary hypertension (PH) and cardiac function for lung transplant (LT) candidates. However, the impact of these metrics on post\u2010LT outcomes remains unclear. We performed a single\u2010center retrospective study of adult LT recipients from 2010 to 2022 to evaluate how RHC and echocardiographic variables relate to mortality, length of stay (LOS), duration of mechanical ventilation (MV), and rejection. An unsupervised cluster analysis was used to identify hemodynamic subgroups with adverse outcomes. Among 297 patients undergoing single or bilateral LT, most had interstitial lung disease (ILD; 52%), followed by chronic obstructive pulmonary disease (COPD; 32%) and other diagnoses (16%); mortality did not differ by indication (COPD 51%, ILD 37%, other 45%;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.10), by PH defined as mean pulmonary artery pressure (mPAP)\u2009&gt;\u200920\u2009mmHg or pulmonary vascular resistance (PVR)\u2009\u2265\u20092 Woods Units (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.45 for each), or by PH classification (isolated post\u2010capillary, combined pre\/post\u2010capillary, or no PH;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.77). However, in COPD, a higher mPAP, right ventricular (RV) filling pressures, and echocardiographic indices of diastolic function and RV pressure overload were associated with greater mortality. Across the cohort, PH was associated with longer LOS, more MV days, and higher rejection rates. Unsupervised cluster analysis identified a subgroup with elevated biventricular filling pressures and RV dysfunction consistent with a congestive hemodynamic footprint that had worse event\u2010free post\u2010LT survival (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.049). These findings highlight the value of integrated invasive and noninvasive hemodynamics beyond the assessment of PH in LT recipients.\n                  <\/jats:p>","DOI":"10.1002\/pul2.70367","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T07:46:18Z","timestamp":1787298378000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Congestive Hemodynamic Footprint Is Associated With Worse Clinical Outcomes in Lung Transplant Recipients"],"prefix":"10.1002","volume":"16","author":[{"given":"Mahmoud","family":"Kabbani","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Cardiology University of Texas Health at San Antonio San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varsha","family":"Karanam","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Washington Medical Center Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3811-4973","authenticated-orcid":false,"given":"Vivek","family":"Jani","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology Johns Hopkins Medical Center Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seamus","family":"Hughes","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology Duke University Hospital Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tess","family":"Allan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology Duke University Hospital Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Diaz","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology Duke University Hospital Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1085-3827","authenticated-orcid":false,"given":"Arun","family":"Rajaratnam","sequence":"additional","affiliation":[{"name":"Deparment of Medicine, Division of General Internal Medicine Duke University Hospital Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina M.","family":"Tilley","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Baylor College of Medicine Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditi","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology University of Texas Health at San Antonio San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima","family":"Dollar","sequence":"additional","affiliation":[{"name":"Department of Thoracic Medicine and Surgery Temple University Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan","family":"Saenger","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology University of Texas Health at San Antonio San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Teng","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology University of Texas Health at San Antonio San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahnoor","family":"Liaqat","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Texas at Austin Dell Medical School Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon","family":"Scott","sequence":"additional","affiliation":[{"name":"School of Medicine University of Texas Health at San Antonio San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9380-0856","authenticated-orcid":false,"given":"Rodolfo A.","family":"Estrada","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Pulmonary and Critical Care University of Texas Health at San Antonio San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly","family":"Keyt","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Pulmonary and Critical Care University of Texas Health at San Antonio San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7216-2613","authenticated-orcid":false,"given":"Allen S.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology University of Texas Health at San Antonio San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Imran","family":"Aslam","sequence":"additional","affiliation":[{"name":"CardioVascular Center Tufts Medical Center Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,21]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S359873"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01914-2018"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/15412555.2015.1043425"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.09.004"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2017.04.010"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2015.01.002"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.029024"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac237"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2024.06.007"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2023.09.031"},{"key":"e_1_2_12_12_1","first-page":"2825","article-title":"Scikit\u2010Learn: Machine Learning in Python","volume":"12","author":"Pedregosa F.","year":"2011","journal-title":"Journal of Machine Learning Research"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1214\/08-AOAS169"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.985515"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2020.12.028"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2004.10.014"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201201-0034OC"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.051540"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-015-9696-8"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.05.010"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.118.008666"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-022-02495-y"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2018.03.46"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy809"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics14131340"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.124.4.1232"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201210-1865OC"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02136-2015"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2021.07.012"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-1903"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.039136"}],"container-title":["Pulmonary Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pul2.70367","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pul2.70367","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pul2.70367","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T15:32:32Z","timestamp":1793028752000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pul2.70367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/pul2.70367"],"URL":"https:\/\/doi.org\/10.1002\/pul2.70367","archive":["Portico"],"relation":{},"ISSN":["2045-8940","2045-8940"],"issn-type":[{"value":"2045-8940","type":"print"},{"value":"2045-8940","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2025-12-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70367"}}