{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:58:02Z","timestamp":1790841482764,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":72,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pulm. circ."],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Tricuspid annular plane systolic excursion (TAPSE) is primarily measured using motion\u2010mode (M\u2010mode) echocardiography. However, image resolution doesn't always provide clear visualization. In these cases, tissue Doppler imaging (TDI) may offer a valuable alternative for right ventricular assessment. To validate TDI\u2010derived TAPSE (TAPSE\u2010TDI) against M\u2010mode TAPSE and compare their diagnostic utility for right heart catheterization\u2010confirmed pulmonary hypertension(PH). We analyzed 304 healthy volunteers and 310 PH patients in a case\u2010control study. M\u2010mode TAPSE and TAPSE\u2010TDI were measured in the RV\u2010focused apical four\u2010chamber view. TAPSE\u2010TDI was calculated by averaging the systolic and diastolic signals from the lateral tricuspid annulus. Agreement between methods was quantified using bias, percentile precision, and intra\u2010class coefficient (ICC). The dependence of annular motion on body size, sex, and heart rate was evaluated with weighted regression. We assessed PH discrimination using receiver operating curve (ROC) analysis, comparing TAPSE, TAPSE\u2010TDI, and RV TDI peak systolic velocity (s\u2032). Thresholds were further tested using Classification and Regression Tree (CART) analysis. TAPSE\u2010TDI demonstrated a strong linear relationship with TAPSE (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.945,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and a slope of 1.02 in no\u2010intercept regression. TAPSE\u2010TDI demonstrated excellent reproducibility (ICC\u2009=\u20090.937), and its reference range fell within the guideline\u2010recommended values. For PH diagnosis, TAPSE and TAPSE\u2010TDI showed good discrimination (AUC\u2009&gt;\u20090.83), with the TAPSE\/RVSP ratio outperforming (both AUC\u2009&gt;\u20090.96). CART analysis identified optimal thresholds of 16.68\u2009mm for TAPSE and 15.88\u2009mm for TAPSE\u2010TDI to discriminate PH. TAPSE measured using TDI was closely related to M\u2010mode and both better discriminated PH than RV s\u2032.\n                  <\/jats:p>","DOI":"10.1002\/pul2.70372","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T16:49:24Z","timestamp":1789145364000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Validation of Tricuspid Annular Displacement by Tissue Doppler in Pulmonary Hypertension"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1541-9733","authenticated-orcid":false,"given":"Rongrong","family":"Chen","sequence":"first","affiliation":[{"name":"Stanford Cardiovascular Institute Stanford University Stanford California USA"},{"name":"Department of Ultrasound Zhangzhou Affiliated Hospital of Fujian Medical University Zhangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shadi P.","family":"Bagherzadeh","sequence":"additional","affiliation":[{"name":"Stanford Cardiovascular Institute Stanford University Stanford California USA"},{"name":"Division of Cardiovascular Medicine, Department of Medicine Stanford University Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neev","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Nephrology Stanford University School of Medicine Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Khoury","sequence":"additional","affiliation":[{"name":"Stanford Cardiovascular Institute Stanford University Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3499-6902","authenticated-orcid":false,"given":"Bettia E.","family":"Celestin","sequence":"additional","affiliation":[{"name":"Stanford Cardiovascular Institute Stanford University Stanford California USA"},{"name":"Division of Pathology, Department of Medicine Stanford University Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frida N.","family":"Hermansson","sequence":"additional","affiliation":[{"name":"Stanford Cardiovascular Institute Stanford University Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer P.","family":"Woo","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine Stanford University Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois","family":"Haddad","sequence":"additional","affiliation":[{"name":"Stanford Cardiovascular Institute Stanford University Stanford California USA"},{"name":"Division of Cardiovascular Medicine, Department of Medicine Stanford University Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeab065"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.661983"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2025.01.006"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.2000.2296"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jen130"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeu040"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2013.02.005"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ihj.2017.06.007"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00879-2022"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.10.003"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-34245-1"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2589-7500(21)00235-1"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-019-0406-y"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-8932(10)70183-4"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(84)90095-4"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.837584"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8175.2007.00424.x"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200604-547OC"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.124.038616"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.14500"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euje.2004.11.002"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2021.06.013"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2024.09.010"}],"container-title":["Pulmonary Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pul2.70372","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pul2.70372","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pul2.70372","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:19:37Z","timestamp":1790839177000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pul2.70372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/pul2.70372"],"URL":"https:\/\/doi.org\/10.1002\/pul2.70372","archive":["Portico"],"relation":{},"ISSN":["2045-8940","2045-8940"],"issn-type":[{"value":"2045-8940","type":"print"},{"value":"2045-8940","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2025-11-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70372"}}