{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:58:02Z","timestamp":1790841482785,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":33,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270062"],"award-info":[{"award-number":["82270062"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["L2424223"],"award-info":[{"award-number":["L2424223"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7242096"],"award-info":[{"award-number":["7242096"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pulm. circ."],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The gut microbiota has been implicated in pulmonary vascular diseases, yet a direct causal link to pulmonary embolism (PE) remains unestablished. This study aimed to investigate the causal effects of gut microbiota on PE and to explore the mediating role of circulating metabolites in this relationship. We performed a two\u2010sample Mendelian randomization (MR) analysis using summary statistics from large\u2010scale genome\u2010wide association studies. The gut microbiota data were sourced from the MiBioGen consortium, PE data from the FinnGen consortium (R10), and metabolite data from a meta\u2010analysis of 136,016 participants. The inverse variance weighting method was used as the primary analytical approach, supplemented by sensitivity analyzes to ensure robustness. At the nominal level (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05), 12 gut microbial taxa showed suggestive associations with PE. Among these, genera LachnospiraceaeUCG010 and Defluviitaleaceae showed protective effects, while Subdoligranulum, Lentisphaerae, and Erysipelatoclostridium were associated with increased risk. In contrast, 26 circulating metabolites exhibited robust causal associations with PE, with several surviving Bonferroni correction. Mediation analyzes further revealed that specific metabolites, including histidine, triglycerides in small HDL, and docosahexaenoic acid ratio, significantly mediated the suggestive effects of nominal microbial taxa on PE risk, identifying potential metabolic pathways in the gut\u2010vascular axis. This study generates hypothesis\u2010generating evidence for the gut\u2010pulmonary vascular axis, with identified metabolic mediators warranting further experimental validation. The potential effects of gut microbiota on PE provide exploratory leads for future mechanistic studies. These findings highlight the gut\u2010pulmonary vascular axis as a potential target for novel preventive and therapeutic strategies against PE.\n                  <\/jats:p>","DOI":"10.1002\/pul2.70376","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T10:07:17Z","timestamp":1785751637000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Causal Role of Gut Microbiota in Pulmonary Embolism and the Mediating Effects of Circulating Metabolites: A Mendelian Randomization Study"],"prefix":"10.1002","volume":"16","author":[{"given":"Yidan","family":"Gao","sequence":"first","affiliation":[{"name":"School of Basic Medicine Inner Mongolia Medical University Hohhot China"},{"name":"State Key Laboratory of Respiratory Health and Multimorbidity, Institute of Basic Medical Sciences &amp; School of Basic Medicine Chinese Academy of Medical Sciences &amp; Peking Union Medical College Beijing 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