{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T15:43:26Z","timestamp":1793029406288,"version":"4.5.0"},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pulm. circ."],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Despite major advances in antiretroviral treatment, pulmonary arterial hypertension (PAH) remains a common, severe complication in patients diagnosed with HIV. Treatment of HIV\u2010associated PAH targets the nitric oxide, endothelin, and prostacyclin pathways, with limited evidence for novel therapies, as these patients have been excluded from most pivotal randomized controlled trials. We report a 58\u2010year\u2010old male with HIV\u2010PAH on dual oral PAH\u2010targeted therapy who developed acute right ventricular (RV) failure triggered by sepsis. Despite escalation of guideline\u2010directed therapy with intravenous prostacyclin and catecholamines, the patient continued to exhibit decompensated right heart failure. Sotatercept was initiated, after which the patient showed marked improvement within 24\u2009h, including improved echocardiographic RV function, a decline in NT\u2010proBNP, recovery of renal function, and successful weaning from catecholamines and prostacyclin. The patient was subsequently transferred to a general ward in stable condition. This case suggests a potential role for sotatercept as rescue therapy in acute decompensated HIV\u2010PAH, with a rapid temporal association with hemodynamic improvement. Further randomized controlled studies are warranted in this high\u2010risk population.<\/jats:p>","DOI":"10.1002\/pul2.70379","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:03:50Z","timestamp":1785150230000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sotatercept Rescue Therapy for Acute Right Heart Failure in HIV\u2010Associated PAH"],"prefix":"10.1002","volume":"16","author":[{"given":"Yaosi","family":"Li","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Respiratory Medicine and Critical Care, Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Grund","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Respiratory Medicine and Critical Care, Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5615-0214","authenticated-orcid":false,"given":"Nils","family":"Kremer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus\u2010Liebig\u2010University Giessen Giessen Hesse Germany"},{"name":"Institute for Lung Health (ILH), Cardio\u2010Pulmonary Institute (CPI) Giessen Hesse Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"M\u00fcller\u2010Redetzky","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Respiratory Medicine and Critical Care, Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Zajonz","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Respiratory Medicine and Critical Care, Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7295-8128","authenticated-orcid":false,"given":"Christian","family":"Gaebler","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Respiratory Medicine and Critical Care, Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Witzenrath","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Respiratory Medicine and Critical Care, Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2834-7466","authenticated-orcid":false,"given":"Horst","family":"Olschewski","sequence":"additional","affiliation":[{"name":"Department of 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