{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T15:43:42Z","timestamp":1793029422076,"version":"4.5.0"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":43,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pulm. circ."],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Pulmonary arterial hypertension (PAH) is a progressive illness that may require therapy with parenteral prostacyclin pathway agents (PPA) (epoprostenol and treprostinil). These parenteral PPA\n                    <jats:styled-content>'<\/jats:styled-content>\n                    s are continuous ambulatory infusions that require a high level of skill and knowledge to maintain safety and effectiveness. Depending on the clinical context, transition to oral prostacyclin receptor agonist therapy (selexipag) is sometimes pursued. To prevent abrupt withdrawal from parenteral PPA's, overlap transitions are typically used. This report describes 35 inpatient, rapid transitions from parenteral PPA's to oral selexipag. Planned hospital admissions for transition were common (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200927, 77%), and all patients successfully transitioned without a return to parenteral PPA's in the immediate post\u2010transition period. Most patients transitioned due to difficulties with current parenteral PPA therapy (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200920, 57%), followed by an improved clinical status on parenteral PPA therapy (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20098, 23%). The median length of transition was 36\u2009h (IQR 24\u201348\u2009h) and hospital stay was 3 days (IQR 2\u20136 days). Following transition, the cohort demonstrated stability in PAH\u2010specific risk scores and functional status. All patients survived to outpatient pulmonary hypertension follow up (median 5.5 weeks, IQR 1.4\u20139.6 weeks), and the majority were alive at 1\u2010year post\u2010transition (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200932, 91%). Based on these results, we conclude that transition from parenteral PPA's to selexipag can be done in the inpatient setting safely, quickly, and effectively.\n                  <\/jats:p>","DOI":"10.1002\/pul2.70383","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T11:22:01Z","timestamp":1786620121000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Transitions From Parenteral Prostacyclin Analogues to Selexipag in Patients With Pulmonary Arterial Hypertension"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2782-1322","authenticated-orcid":false,"given":"Dalton J.","family":"Kuebel","sequence":"first","affiliation":[{"name":"Division of Pharmacy Practice and Administrative Sciences University of Cincinnati James L. Winkle College of Pharmacy Cincinnati Ohio USA"},{"name":"Department of Pharmacy Services UC Health \u2013 University of Cincinnati Medical Center Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adele R.","family":"Collins","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine University of Cincinnati Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7109-2692","authenticated-orcid":false,"given":"Arun","family":"Jose","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine University of Cincinnati Cincinnati Ohio USA"},{"name":"Cincinnati VA Medical Center Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria R.","family":"Guido","sequence":"additional","affiliation":[{"name":"Division of Pharmacy Practice and Administrative Sciences University of Cincinnati James L. Winkle College of Pharmacy Cincinnati Ohio USA"},{"name":"UC Health \u2013 Pharmacy Administration Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6199-1707","authenticated-orcid":false,"given":"Jean M.","family":"Elwing","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine University of Cincinnati Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac237"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0095-2017"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000526190"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2021.102100"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/20458940211036623"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.14428"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.909595"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp170814"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000000800"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/mrcr\/rxac009"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/23971983211063711"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/2045894020931324"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/2045893217706357"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2020.08.2069"}],"container-title":["Pulmonary Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pul2.70383","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pul2.70383","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pul2.70383","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T15:31:36Z","timestamp":1793028696000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pul2.70383"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/pul2.70383"],"URL":"https:\/\/doi.org\/10.1002\/pul2.70383","archive":["Portico"],"relation":{},"ISSN":["2045-8940","2045-8940"],"issn-type":[{"value":"2045-8940","type":"print"},{"value":"2045-8940","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-01-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70383"}}