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Recent investigations have unveiled HIFs' ability to orchestrate a wide array of signaling cascades, encompassing voltage\u2010gated potassium channels, non\u2010selective cation channels (NSCCs), Ca\n                    <jats:sup>2+<\/jats:sup>\n                    \/PKC\/MAPKs, PI3K\/Akt, RhoA\/ROCK, Notch, VEGF, and miRNA pathways. The interplay of these signaling cascades drives critical events, namely hypoxic pulmonary vasoconstriction (HPV) and hypoxic pulmonary vascular remodeling (HPVR), which collectively contribute to the pathogenesis of PH. 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