{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:58:37Z","timestamp":1790841517774,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":83,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pulm. circ."],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Pulmonary arterial hypertension (PAH) was historically viewed as a disease of young adults; however, emerging evidence suggests rising prevalence in the elderly, which is an insufficiently characterized population. We evaluated clinical and sociodemographic features of PAH patients over 80 years and compared their outcomes with younger patients. We performed a prospective cohort study utilizing the Pulmonary Hypertension Association Registry to compare clinical characteristics, functional capacity, and quality of life measures between octogenarians (\u2265\u200980 years) and non\u2010octogenarians (&lt;\u200980 years) at enrollment and follow\u2010up visits. Associations between age subgroups and outcomes were assessed using linear, binomial, and Cox regression. The cohort comprised 113 octogenarians and 3,094 non\u2010octogenarians with PAH. Smoking history was more common in octogenarians, who also more frequently had idiopathic or connective tissue disease\u2013related PAH. Octogenarians had lower right atrial pressure and mean pulmonary artery pressure (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) than younger patients. At baseline, octogenarians had a lower absolute 6\u2010min walk distance and higher World Health Organization functional class (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Octogenarians were more often initially treated with monotherapy and less likely to receive a prostacyclin analog. Octogenarians had a 57% higher risk of all\u2010cause hospitalization and twice the mortality of younger adults after covariate adjustment (IRR 1.57, 95%CI 1.06\u20132.33,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05 and HR 2.38, 95%CI 1.62\u20133.52,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001, respectively). The oldest PAH patients exhibit distinct clinical profiles, therapies, and outcomes compared to younger adults, though it remains uncertain whether these differences reflect a unique phenotype, reduced therapy response, or the cumulative effects of aging and comorbid conditions.\n                  <\/jats:p>","DOI":"10.1002\/pul2.70387","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T08:56:37Z","timestamp":1790067397000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pulmonary Arterial Hypertension in Octogenarians: The Pulmonary Hypertension Association Registry"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9561-4467","authenticated-orcid":false,"given":"Renuka","family":"Reddy","sequence":"first","affiliation":[{"name":"Pulmonary, Allergy and Critical Care Division Perelman School of Medicine at the University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jude","family":"Moutchia","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Epidemiology, and Informatics Perelman School of Medicine at the University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashwin","family":"Ravichandran","sequence":"additional","affiliation":[{"name":"Division of Cardiology Ascension St Vincent Hospital Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Runo","sequence":"additional","affiliation":[{"name":"Division of Allergy, Pulmonary and Critical Care Medicine University of Wisconsin Madison WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6311-4828","authenticated-orcid":false,"given":"David B.","family":"Badesch","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Sciences and Critical Care Medicine University of Colorado Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Moss","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Allergy and Sleep Medicine, Mayo Clinic Jacksonville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4815-3669","authenticated-orcid":false,"given":"Charles","family":"Burger","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Allergy and Sleep Medicine, Mayo Clinic Jacksonville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0183-4704","authenticated-orcid":false,"given":"Teresa","family":"De Marco","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of California San Francisco San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5751-9415","authenticated-orcid":false,"given":"Evelyn","family":"Horn","sequence":"additional","affiliation":[{"name":"Division of Cardiology Cornell University New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8505-1680","authenticated-orcid":false,"given":"Ali","family":"Ataya","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine University of Florida Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9433-3049","authenticated-orcid":false,"given":"Andrew","family":"Bryant","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine University of Florida Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0437-3213","authenticated-orcid":false,"given":"Nadine","family":"Al\u2010Naamani","sequence":"additional","affiliation":[{"name":"Pulmonary, Allergy and Critical Care Division Perelman School of Medicine at the University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7896-0608","authenticated-orcid":false,"given":"Steven M.","family":"Kawut","sequence":"additional","affiliation":[{"name":"Pulmonary, Allergy and Critical Care Division Perelman School of Medicine at the University of Pennsylvania Philadelphia PA USA"},{"name":"Department of Biostatistics, Epidemiology, and Informatics Perelman School of Medicine at the University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the PHAR Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,22]]},"reference":[{"issue":"1","key":"e_1_2_13_2_1","first-page":"11","article-title":"Epidemiology of Pulmonary Hypertension in the Elderly","volume":"14","author":"\u00d6rem C.","year":"2017","journal-title":"Journal of Geriatric 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A.","year":"2018","journal-title":"Revista da Escola de Enfermagem da U S P"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000030169"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2024.11.027"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11113-015-9379-4"},{"key":"e_1_2_13_29_1","volume-title":"U.S. State Life Tables","author":"Arias E.","year":"2024"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.024969"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S123173"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00100-2018"}],"container-title":["Pulmonary Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pul2.70387","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pul2.70387","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pul2.70387","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:19:52Z","timestamp":1790839192000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pul2.70387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/pul2.70387"],"URL":"https:\/\/doi.org\/10.1002\/pul2.70387","archive":["Portico"],"relation":{},"ISSN":["2045-8940","2045-8940"],"issn-type":[{"value":"2045-8940","type":"print"},{"value":"2045-8940","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-04-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70387"}}