{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T15:43:37Z","timestamp":1793029417154,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":68,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pulm. circ."],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Pulmonary arterial hypertension (PAH) is a life\u2010limiting disease with psychosocial burden, although US population\u2010level estimates of incident mental health (MH) disorders remain limited. In this retrospective cohort study using Komodo Research Data (01\/01\/2016\u221203\/31\/2024), we evaluated the association between PAH diagnosis and risk of newly diagnosed MH conditions. Adults (\u2265\u200918 years) with incident PAH were identified alongside a non\u2010PAH control group. Among patients with PAH (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u20094005), the risks of newly diagnosed MH conditions were compared before and after the PAH diagnosis date (index date). Between\u2010group comparisons of newly diagnosed MH conditions post\u2010index used inverse probability weighting to balance PAH and non\u2010PAH patients. Outcomes included 12\u2010month cumulative incidence and hazard ratios (HRs) from Cox models for any MH condition and prespecified categories (anxiety, mood, sleep\u2010wake, substance use). Post\u2010diagnosis, the 12\u2010month risk of any newly diagnosed MH condition nearly doubled compared with pre\u2010diagnosis (48.1% vs 24.9%; HR: 2.29;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Post\u2010diagnosis risks were also higher for sleep\u2010wake (27.1% vs 11.5%; 2.59), anxiety\u2010spectrum (11.4% vs 8.4%; 1.37), mood (9.7% vs 6.0%; 1.65), and opioid use disorders (1.5% vs 0.7%; 2.07; all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Compared with matched controls (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u2009421,987), PAH patients had higher risks of any MH condition (39.5% vs 17.8%; HR: 2.57), anxiety (10.1% vs 6.5%; 1.58), mood (8.7% vs 5.3%; 1.68), and substance use disorders (5.2% vs 3.4%; 1.53; all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Adults with PAH experienced marked increases in newly diagnosed MH conditions after PAH onset and significantly higher risk than matched non\u2010PAH controls, supporting routine MH screening and integrated, proactive MH care in PAH management.\n                  <\/jats:p>","DOI":"10.1002\/pul2.70398","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T15:12:37Z","timestamp":1788793957000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Incident Pulmonary Arterial Hypertension on Risk of Newly\u2010Diagnosed Mental Health Conditions"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8897-9339","authenticated-orcid":false,"given":"Anna","family":"Watzker","sequence":"first","affiliation":[{"name":"Merck &amp; Co., Inc. Rahway New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Patterson\u2010Lomba","sequence":"additional","affiliation":[{"name":"Analysis Group, Inc. Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6766-1560","authenticated-orcid":false,"given":"Cameron","family":"Fowler","sequence":"additional","affiliation":[{"name":"Analysis Group, Inc. Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7566-2813","authenticated-orcid":false,"given":"Yan","family":"Song","sequence":"additional","affiliation":[{"name":"Analysis Group, Inc. Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4988-5594","authenticated-orcid":false,"given":"Alejandro","family":"Victores","sequence":"additional","affiliation":[{"name":"Merck &amp; Co., Inc. Rahway New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alen","family":"Dezia","sequence":"additional","affiliation":[{"name":"Merck &amp; Co., Inc. Rahway New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayang","family":"Li","sequence":"additional","affiliation":[{"name":"Analysis Group, Inc. Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azeem","family":"Banatwala","sequence":"additional","affiliation":[{"name":"Analysis Group, Inc. Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyi","family":"Cai","sequence":"additional","affiliation":[{"name":"Analysis Group, Inc. Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7964-8322","authenticated-orcid":false,"given":"Lana","family":"Melendres\u2010Groves","sequence":"additional","affiliation":[{"name":"University of New Mexico Albuquerque New Mexico USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-015-9517-4"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00007813"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-019-0595-x"},{"issue":"16","key":"e_1_2_13_5_1","first-page":"1","article-title":"Patient Experiences of Depression and Anxiety With Chronic Disease: A Systematic Review and Qualitative Meta\u2010Synthesis","volume":"13","author":"DeJean D.","year":"2013","journal-title":"Ontario Health Technology Assessment Series"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.4402"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-024-01064-4"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.37765\/ajmc.2021.88609"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.024969"},{"key":"e_1_2_13_10_1","first-page":"1","article-title":"Economic Burden Associated With Pulmonary Arterial Hypertension in the United States","volume":"43","author":"Watzker A.","year":"2024","journal-title":"PharmacoEconomics"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-023-00486-7"},{"issue":"15","key":"e_1_2_13_12_1","first-page":"4983","article-title":"Quality of Life of Patients With Pulmonary Arterial Hypertension: A Meta\u2010Analysis","volume":"25","author":"Sarzy\u0144ska K.","year":"2021","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2023.08.004"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/17534666231218886"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00617-2020"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.765461"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.667602"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000524369"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrtlng.2017.12.004"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-7-55"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0063-2015"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202010-3967LE"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-021-01782-0"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCN.0b013e318275330d"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-3182(10)70706-4"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-14-104"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.813506"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000445805"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9124023"},{"issue":"6","key":"e_1_2_13_30_1","article-title":"Suicidal Ideation, Self\u2010Esteem, and Hopelessness in Patients With Pulmonary Arterial Hypertension","volume":"23","author":"Korkmaz S.","year":"2021","journal-title":"Primary Care Companion for CNS Disorders"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/2045894020961713"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac237"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425787"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlr.0000182534.19832.83"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2018.11.030"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjhp.12800"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.2147\/vhrm.S147173"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00526-2021"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/crj.13685"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-017-9640-5"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2015.5220"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00063108"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41533-019-0119-9"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.14207"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2020.12.010"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/pul2.70256"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2024.02.004"}],"container-title":["Pulmonary Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pul2.70398","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pul2.70398","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pul2.70398","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T15:32:00Z","timestamp":1793028720000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pul2.70398"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":46,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/pul2.70398"],"URL":"https:\/\/doi.org\/10.1002\/pul2.70398","archive":["Portico"],"relation":{},"ISSN":["2045-8940","2045-8940"],"issn-type":[{"value":"2045-8940","type":"print"},{"value":"2045-8940","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-04-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70398"}}