{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:58:50Z","timestamp":1790841530955,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":63,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pulm. circ."],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Pulmonary hypertension caused by fibrosing mediastinitis (PH\u2010FM) is a high\u2010risk condition with limited validated tools for prognostic assessment. Although diffusing capacity of the lung for carbon monoxide (DLCO) predicts outcomes in several cardiopulmonary diseases, its prognostic value in PH\u2010FM remains unclear. In this multicenter retrospective cohort study, we included 106 patients with confirmed PH\u2010FM from 14 centers across China. The primary endpoint was all\u2010cause mortality. Cox proportional hazards models were used to assess the association between baseline percent\u2010predicted DLCO and mortality, with sequential adjustment for clinical, hemodynamic, and spirometric variables. The final cohort included 106 patients, of whom 60 had DLCO\u2009\u2265\u200960% predicted and 46 had DLCO\u2009&lt;\u200960% predicted. Over a median follow\u2010up of 36 months (interquartile range [IQR], 14.0\u201350.8), 27 deaths occurred. Across Cox models, each 10\u2010percentage\u2010point increase in percent\u2010predicted DLCO was associated with a 30% lower risk of all\u2010cause mortality. DLCO\u2009&lt;\u200960% predicted was associated with higher all\u2010cause mortality compared with DLCO\u2009\u2265\u200960% predicted, with hazard ratios ranging from 6.90 to 7.80 across models. Lower baseline percent\u2010predicted DLCO was independently associated with a higher risk of all\u2010cause mortality in patients with PH\u2010FM. DLCO may provide a simple, noninvasive measure to complement current risk assessment in this population.<\/jats:p>","DOI":"10.1002\/pul2.70401","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T09:55:47Z","timestamp":1788342947000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diffusing Capacity of the Lung for Carbon Monoxide and the Risk of All\u2010Cause Mortality in Patients With Pulmonary Hypertension Caused by Fibrosing Mediastinitis: A Multicenter Cohort Study"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2362-308X","authenticated-orcid":false,"given":"Mengyu","family":"Wu","sequence":"first","affiliation":[{"name":"Heart, Lung and Vessels Center, Sichuan Provincial People's Hospital University of Electronic Science and Technology of China, Ultrasound Medicine and Computational Cardiology Key Laboratory of Sichuan Province Chengdu 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