{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:58:50Z","timestamp":1790841530905,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":65,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["T32 5T32HL007171\u201048"],"award-info":[{"award-number":["T32 5T32HL007171\u201048"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pulm. circ."],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Pulmonary arterial hypertension (PAH) in Latin America and the Caribbean (LAC) remains poorly characterized, with limited regional data on clinical presentation, hemodynamics, treatment patterns, and outcomes. We aimed to characterize demographic features, clinical presentation, hemodynamic severity, treatment patterns, and survival outcomes of right heart catheterization\u2010confirmed PAH cohorts across LAC. We performed a systematic review and meta\u2010analysis of retrospective and prospective cohort studies of adults with right heart catheterization\u2010confirmed PAH in LAC, searching six databases in English, Spanish, and Portuguese without date restrictions. Study\u2010level aggregate data were pooled using random\u2010effects models. Sixteen studies from eight countries (1999\u20132025) including 2,553 patients were analyzed. Mean age was 43.6 years and 81.5% were female. Etiologies included idiopathic PAH (40.3%), congenital heart disease\u2010associated PAH (25.6%), connective tissue disease\u2010associated PAH (20.6%), and schistosomiasis\u2010associated PAH (15.3% in Brazilian cohorts). At diagnosis, 51% were in functional class III\/IV, mean 6\u2010min walk distance was 406\u2009m, mean pulmonary arterial pressure was 55.8\u2009mmHg, and cardiac index was 2.63\u2009L\/min\/m\n                      <jats:sup>2<\/jats:sup>\n                      . Treatment consisted primarily of monotherapy (56%) or dual therapy (33%). Pooled survival was 93.9% at 1 year, 87.5% at 2 years, and 83.0% at 3 years. Predominantly reflecting South American PAH care, our findings establish the first regional benchmark for PAH in LAC. Patients are younger and predominantly female, with a high burden of CHD\u2010PAH and schistosomiasis\u2010associated PAH. Despite delayed diagnosis and limited combination therapy access, survival is comparable to high\u2010income registries, highlighting priorities such as earlier referral, risk assessment, expanded therapy access, and prospective registry development.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trail Registration<\/jats:title>\n                    <jats:p>PROSPERO CRD420251131636.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pul2.70403","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T10:46:33Z","timestamp":1788518793000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pulmonary Arterial Hypertension in Latin America: Characteristics, Treatment, and Survival From the LATAM\u2010PAH Meta\u2010Analysis and Systematic Review"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4730-3650","authenticated-orcid":false,"given":"Marcos Vinicius","family":"Fernandes Garcia","sequence":"first","affiliation":[{"name":"Division of Pulmonary, Allergy and Critical Care Medicine University of Colorado Anschutz Medical Campus Aurora Colorado USA"},{"name":"Division of Pulmonary, Critical Care &amp; Sleep Medicine National Jewish Health Denver Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Julian","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine University of Colorado Anschutz Medical Campus Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evans R.","family":"Fern\u00e1ndez P\u00e9rez","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care &amp; Sleep Medicine National Jewish Health Denver Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2789-9143","authenticated-orcid":false,"given":"Rogerio","family":"Souza","sequence":"additional","affiliation":[{"name":"Pulmonary Division, Heart Institute (InCor) Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de Sao Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0007-6606","authenticated-orcid":false,"given":"Tim","family":"Lahm","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy and Critical Care Medicine University of Colorado Anschutz Medical Campus Aurora Colorado USA"},{"name":"Division of Pulmonary, Critical Care &amp; Sleep Medicine National Jewish Health Denver Colorado USA"},{"name":"Rocky Mountain Regional Veterans Affairs Medical Center Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2000348"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-018-0667-8"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.03.047"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arbres.2025.12.002"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2024-087263"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(24)00295-9"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cl2.1230"},{"key":"e_1_2_11_11_1","unstructured":"Public Health England.Funnel Plot Tool for Proportions https:\/\/fingertips.phe.org.uk\/profile\/guidance2017[Accessed September2025]."},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-021-01308-8"},{"issue":"2","key":"e_1_2_11_13_1","first-page":"144","article-title":"Hipertensi\u00f3n Arterial Pulmonar. 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