{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:55:55Z","timestamp":1791287755528,"version":"4.3.0"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pulm. circ."],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Pulmonary hypertension (PH) is common in patients undergoing transcatheter mitral edge\u2010to\u2010edge repair (M\u2010TEER) and is an established determinant of adverse outcomes after intervention. Importantly, persistent PH after technically successful M\u2010TEER remains associated with ongoing symptoms, right ventricular dysfunction and poor prognosis, yet no dedicated treatment strategy has been established. The aim of this study is to evaluate the safety and efficacy of pulmonary artery denervation (PADN) in patients with persistent PH following successful M\u2010TEER. Six patients (median age 69.0 years; 1 female) with WHO Group 2 PH and persistent symptoms despite successful M\u2010TEER underwent PADN at a median of 583 days after valve repair. All patients had trace to mild residual MR (grade 1+) with median mean mitral valve gradient 3.0\u2009mmHg. Right heart catheterization (RHC) was performed at baseline, immediately post\u2010PADN, and at 6\u2010month follow\u2010up. Immediately post\u2010PADN, mean pulmonary artery pressure (mPAP) decreased from 38.5 (3.8) mmHg to 34.0 (11.5) mmHg (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.028). Pulmonary arterial wedge pressure decreased from 22.5 (7.5) mmHg to 20.0 (6.2) mmHg (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.026). At 6\u2010month follow\u2010up, a directional but statistically non\u2010significant trend toward maintained mPAP reduction was observed [median 32.5 (9.0) mmHg vs. baseline 38.5 (3.8) mmHg;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.075]. Tricuspid regurgitation grade improved in 5 of 6 patients (83%). Median 6\u2010min walk distance increased from 377 (109) m to 436 (109) m (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.046). No procedural complications occurred. PADN appears feasible, safe, and potentially effective in patients with persistent PH following M\u2010TEER, warranting further investigation in controlled studies.\n                  <\/jats:p>","DOI":"10.1002\/pul2.70404","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:34:14Z","timestamp":1791286454000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pulmonary Artery Denervation for Persistent Pulmonary Hypertension After Transcatheter Mitral Edge\u2010to\u2010Edge Repair: A Pilot Study and First Application in the Post M\u2010TEER Setting"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0306-0976","authenticated-orcid":false,"given":"Xiang","family":"Chen","sequence":"first","affiliation":[{"name":"Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine Fujian Branch of National Clinical Research Center for Cardiovascular Diseases Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6793-8904","authenticated-orcid":false,"given":"Zeying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine Fujian Branch of National Clinical Research Center for Cardiovascular Diseases Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Lan","sequence":"additional","affiliation":[{"name":"Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine Fujian Branch of National Clinical Research Center for Cardiovascular Diseases Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weibin","family":"Chen","sequence":"additional","affiliation":[{"name":"Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine Fujian Branch of National Clinical Research Center for Cardiovascular Diseases Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyue","family":"Fang","sequence":"additional","affiliation":[{"name":"Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine Fujian Branch of National Clinical Research Center for Cardiovascular Diseases Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaibin","family":"Huang","sequence":"additional","affiliation":[{"name":"Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine Fujian Branch of National Clinical Research Center for Cardiovascular Diseases Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3887-952X","authenticated-orcid":false,"given":"Shaoliang","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Cardiology Nanjing First Hospital of Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine Fujian Branch of National Clinical Research Center for Cardiovascular Diseases Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"issue":"24","key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1056\/NEJMoa1806640","article-title":"Transcatheter Mitral\u2010Valve Repair in Patients With Heart Failure","volume":"379","author":"Stone G. W.","year":"2018","journal-title":"New England Journal of Medicine"},{"issue":"24","key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1056\/NEJMoa1805374","article-title":"Percutaneous Repair or Medical Treatment for Secondary Mitral Regurgitation","volume":"379","author":"Obadia J. F.","year":"2018","journal-title":"New England Journal of Medicine"},{"issue":"22","key":"e_1_2_12_4_1","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1016\/j.jacc.2020.09.609","article-title":"Pulmonary Hypertension in Transcatheter Mitral Valve Repair for Secondary Mitral Regurgitation","volume":"76","author":"Ben\u2010Yehuda O.","year":"2020","journal-title":"Journal of the American College of Cardiology"},{"issue":"20","key":"e_1_2_12_5_1","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1016\/j.jacc.2019.02.075","article-title":"A Unifying Concept for the Quantitative Assessment of Secondary Mitral Regurgitation","volume":"73","author":"Bartko P. E.","year":"2019","journal-title":"Journal of the American College of Cardiology"},{"issue":"12","key":"e_1_2_12_6_1","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1093\/eurheartj\/ehv512","article-title":"Left Ventricular Heart Failure and Pulmonary Hypertension","volume":"37","author":"Rosenkranz S.","year":"2016","journal-title":"European Heart Journal"},{"key":"e_1_2_12_7_1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3389\/fcvm.2018.00040","article-title":"Pulmonary Hypertension in Aortic and Mitral Valve Disease","volume":"5","author":"Maeder M. T.","year":"2018","journal-title":"Frontiers in Cardiovascular Medicine"},{"issue":"6","key":"e_1_2_12_8_1","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1161\/HYPERTENSIONAHA.119.14330","article-title":"Pulmonary Hypertension Due to Left Heart Disease: Diagnosis, Pathophysiology, and Therapy","volume":"75","author":"Al\u2010Omary M. S.","year":"2020","journal-title":"Hypertension"},{"issue":"38","key":"e_1_2_12_9_1","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1093\/eurheartj\/ehac237","article-title":"2022 ESC\/ERS Guidelines for the Diagnosis and Treatment of Pulmonary Hypertension","volume":"43","author":"Humbert M.","year":"2022","journal-title":"European Heart Journal"},{"issue":"11","key":"e_1_2_12_10_1","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.115.002569","article-title":"Pulmonary Artery Denervation Reduces Pulmonary Artery Pressure and Induces Histological Changes in An Acute Porcine Model of Pulmonary Hypertension[J]","volume":"8","author":"Rothman A. M.","year":"2015","journal-title":"Circ Cardiovasc Interv"},{"issue":"12","key":"e_1_2_12_11_1","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/j.jacc.2013.05.075","article-title":"Pulmonary Artery Denervation to Treat Pulmonary Arterial Hypertension","volume":"62","author":"Chen S. L.","year":"2013","journal-title":"Journal of the American College of Cardiology"},{"issue":"3","key":"e_1_2_12_12_1","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.jcin.2018.09.021","article-title":"Pulmonary Artery Denervation Significantly Increases 6\u2010Min Walk Distance for Patients With Combined Pre\u2010 and Post\u2010Capillary Pulmonary Hypertension Associated With Left Heart Failure","volume":"12","author":"Zhang H.","year":"2019","journal-title":"PADN\u20105 Study[J]. JACC Cardiovasc Interv"},{"issue":"11","key":"e_1_2_12_13_1","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1164\/rccm.200912-1856OC","article-title":"Prognostic Significance of Sympathetic Nervous System Activation in Pulmonary Arterial Hypertension","volume":"181","author":"Ciarka A.","year":"2010","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"issue":"1","key":"e_1_2_12_14_1","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1186\/s12872-024-04238-7","article-title":"The Effect of Pulmonary Hypertension and Right Ventricular Dysfunction on Early Mortality and Morbidity in Patients Undergoing Mitral Valve Replacement","volume":"24","author":"Gencoglu F.","year":"2024","journal-title":"BMC Cardiovascular Disorders"},{"issue":"1","key":"e_1_2_12_15_1","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01889-2018","article-title":"Risk Stratification and Medical Therapy of Pulmonary Arterial Hypertension","volume":"53","author":"Gali\u00e8 N.","year":"2019","journal-title":"European Respiratory Journal"},{"issue":"8","key":"e_1_2_12_16_1","first-page":"989","article-title":"Intravascular Ultrasound Pulmonary Artery Denervation to Treat Pulmonary Arterial Hypertension (TROPHY1)","volume":"13","author":"Rothman A. M. K.","year":"2020","journal-title":"JACC: Cardiovascular Interventions"}],"container-title":["Pulmonary Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pul2.70404","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pul2.70404","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pul2.70404","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:34:16Z","timestamp":1791286456000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pul2.70404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/pul2.70404"],"URL":"https:\/\/doi.org\/10.1002\/pul2.70404","archive":["Portico"],"relation":{},"ISSN":["2045-8940","2045-8940"],"issn-type":[{"value":"2045-8940","type":"print"},{"value":"2045-8940","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2026-05-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70404"}}