{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:57:12Z","timestamp":1790848632505,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pulm. circ."],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Mephedrone is a synthetic cathinone with sympathomimetic effects, but has not previously been linked to pulmonary arterial hypertension (PAH). We report a 42\u2010year\u2010old woman with no prior cardiopulmonary disease who presented with severe pre\u2010capillary PAH after a decade of near\u2010daily mephedrone use. Extensive evaluation\u2014including autoimmune, infectious, genetic, and imaging studies\u2014excluded recognised causes of PAH. Following cessation of mephedrone and initiation of dual oral PAH\u2010targeted therapy, she demonstrated substantial initial clinical and haemodynamic improvement; however, the response remained incomplete, necessitating further treatment escalation with selexipag. This appears to be the first reported case of PAH linked to mephedrone use.<\/jats:p>","DOI":"10.1002\/pul2.70415","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:25:06Z","timestamp":1790846706000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pulmonary Arterial Hypertension Associated With Chronic Mephedrone Use: A Case Report"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4103-8174","authenticated-orcid":false,"given":"Masoud","family":"Kashoub","sequence":"first","affiliation":[{"name":"Clinical Fellow Respiratory Medicine, Royal Brompton Hospital Part of Guy's and St Thomas' NHS Foundation Trust London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Plunkett","sequence":"additional","affiliation":[{"name":"National Pulmonary Hypertension Service, Royal Brompton Hospital Part of Guy's and St Thomas' NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heba","family":"Nashat","sequence":"additional","affiliation":[{"name":"National Pulmonary Hypertension Service, Royal Brompton Hospital Part of Guy's and St Thomas' NHS Foundation Trust London UK"},{"name":"National Heart and Lung Institute, Guy Scadding Building Imperial College London London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Dimopoulos","sequence":"additional","affiliation":[{"name":"National Pulmonary Hypertension Service, Royal Brompton Hospital Part of Guy's and St Thomas' NHS Foundation Trust London UK"},{"name":"National Heart and Lung Institute, Guy Scadding Building Imperial College London London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colm","family":"McCabe","sequence":"additional","affiliation":[{"name":"National Pulmonary Hypertension Service, Royal Brompton Hospital Part of Guy's and St Thomas' NHS Foundation Trust London UK"},{"name":"National Heart and Lung Institute, Guy Scadding Building Imperial College London London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl","family":"Harries","sequence":"additional","affiliation":[{"name":"National Pulmonary Hypertension Service, Royal Brompton Hospital Part of Guy's and St Thomas' NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4287-1173","authenticated-orcid":false,"given":"S.","family":"John Wort","sequence":"additional","affiliation":[{"name":"National Pulmonary Hypertension Service, Royal Brompton Hospital Part of Guy's and St Thomas' NHS Foundation Trust London UK"},{"name":"National Heart and Lung Institute, Guy Scadding Building Imperial College London London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul I.","family":"Dargan","sequence":"additional","affiliation":[{"name":"Clinical Toxicology Guy's and St Thomas' NHS Foundation Trust London UK"},{"name":"Faculty of Life Sciences and Medicine King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5250-660X","authenticated-orcid":false,"given":"Laura C.","family":"Price","sequence":"additional","affiliation":[{"name":"National Pulmonary Hypertension Service, Royal Brompton Hospital Part of Guy's and St Thomas' NHS Foundation Trust London UK"},{"name":"National Heart and Lung Institute, Guy Scadding Building Imperial College London London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2011.10.010"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-012-2855-1"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2016.75"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/emj.2010.096636"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2012.04.020"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2010.531021"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2013.05.024"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2016_61"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201705-0943OC"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2024.01.014"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.4402"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00003313"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/15563650.2018.1447119"}],"container-title":["Pulmonary Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pul2.70415","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pul2.70415","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pul2.70415","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:25:07Z","timestamp":1790846707000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pul2.70415"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/pul2.70415"],"URL":"https:\/\/doi.org\/10.1002\/pul2.70415","archive":["Portico"],"relation":{},"ISSN":["2045-8940","2045-8940"],"issn-type":[{"value":"2045-8940","type":"print"},{"value":"2045-8940","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2025-12-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70415"}}