{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T08:43:58Z","timestamp":1792053838173,"version":"4.4.0"},"reference-count":5,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pulm. circ."],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chronic thromboembolic pulmonary hypertension (CTEPH) can be treated by mechanical therapy with pulmonary endarterectomy (PEA) or balloon pulmonary angioplasty (BPA). Haemodynamic treatment goal is ill\u2010defined. We explored post\u2010procedure mean pulmonary arterial pressure (mPAP), pulmonary vascular resistance (PVR), and its relationship with 5\u2010Year survival and exercise capacity Using 6\u2010min Walk Distance (6MWD). Consecutive PEA and BPA patients from the UK CURATE database, treated between 2007 and 2022 and 2015\u20132022, respectively, stratified by 3\u2010month follow\u2010up mPAP and PVR by right heart catheter (RHC), had 5\u2010year survival and 6MWD compared, adjusted for age, sex, drug treatment, and comorbidities in the PEA cohort. Those treated by PEA achieving an mPAP\u2009\u2264\u200925\u2009mmHg had significantly better survival than higher mPAP groups (all pairwise comparisons\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), with no additional survival advantage below mPAP of 25\u2009mmHg. Those with PVR\u2009\u2264\u2009300 dyne.s.cm\n                    <jats:sup>\u22125<\/jats:sup>\n                    also had better 5\u2010year survival (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Continuous PVR modelling showed a 17% decrease in 5\u2010year survival for every 100 dyne.s.cm\n                    <jats:sup>\u22125<\/jats:sup>\n                    increase in post\u2010operative PVR (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). And these results remained significant after proportional hazard modelling. Those treated by BPA achieving an mPAP\u2009\u2264\u200930\u2009mmHg and PVR\u2009\u2264\u2009300 had a significantly better 5\u2010year survival with no additional survival advantage below these values. Continuous PVR modelling showed a 48% decrease in 5\u2010year survival for every 100 dyne.s.cm\n                    <jats:sup>\u22125<\/jats:sup>\n                    increase in post\u2010operative PVR (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.008). In conclusion, post\u2010procedure haemodynamics predict 5\u2010year survival after mechanical therapy for CTEPH. Achieving a mPAP\u2009\u2264\u200925\u2009mmHg for PEA and \u2264\u200930\u2009mmHg for BPA, or a PVR\u2009\u2264\u2009300 dyne.s.cm\n                    <jats:sup>\u22125<\/jats:sup>\n                    for both, conferred a better prognosis.\n                  <\/jats:p>","DOI":"10.1002\/pul2.70419","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T07:46:14Z","timestamp":1792050374000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pulmonary Haemodynamics After Mechanical Therapy With PEA and BPA Predict Survival in Patients With CTEPH \u2010 A Prospective Analysis From the National UK CURATE Registry"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8987-5115","authenticated-orcid":false,"given":"Eilish","family":"Turner\u2010Frick","sequence":"first","affiliation":[{"name":"Royal Papworth Hospital Cambridge UK"},{"name":"University of Cambridge Cambridge Cambridgeshire United\u00a0Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0264-3355","authenticated-orcid":false,"given":"Hakim","family":"Ghani","sequence":"additional","affiliation":[{"name":"Royal Papworth Hospital Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3142-1778","authenticated-orcid":false,"given":"Paula","family":"Appenzeller","sequence":"additional","affiliation":[{"name":"Royal Papworth Hospital Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana","family":"Amaral\u2010Almeida","sequence":"additional","affiliation":[{"name":"Royal Papworth Hospital Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8785-0715","authenticated-orcid":false,"given":"Katherine","family":"Bunclark","sequence":"additional","affiliation":[{"name":"Royal Papworth Hospital Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Cannon","sequence":"additional","affiliation":[{"name":"Royal Papworth Hospital Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7597-4626","authenticated-orcid":false,"given":"Karen","family":"Sheares","sequence":"additional","affiliation":[{"name":"Royal Papworth Hospital Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3969-6143","authenticated-orcid":false,"given":"Mark","family":"Toshner","sequence":"additional","affiliation":[{"name":"Royal Papworth Hospital Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolores","family":"Taboada","sequence":"additional","affiliation":[{"name":"Royal Papworth Hospital Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2502-0484","authenticated-orcid":false,"given":"Choo","family":"Ng","sequence":"additional","affiliation":[{"name":"Royal Papworth Hospital Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1277-6530","authenticated-orcid":false,"given":"John","family":"Taghavi","sequence":"additional","affiliation":[{"name":"Royal Papworth Hospital Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4733-5401","authenticated-orcid":false,"given":"Steven","family":"Tsui","sequence":"additional","affiliation":[{"name":"Royal Papworth Hospital Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Screaton","sequence":"additional","affiliation":[{"name":"Royal Papworth Hospital Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5348-3972","authenticated-orcid":false,"given":"Alessandro","family":"Rugierro","sequence":"additional","affiliation":[{"name":"Royal Papworth Hospital Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2501-8894","authenticated-orcid":false,"given":"Luigia","family":"D'Errico","sequence":"additional","affiliation":[{"name":"Royal Papworth Hospital Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Bambrough","sequence":"additional","affiliation":[{"name":"Royal Papworth Hospital Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3424-5888","authenticated-orcid":false,"given":"J","family":"Gerry Coghlan","sequence":"additional","affiliation":[{"name":"Royal Papworth Hospital Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P","family":"Jenkins","sequence":"additional","affiliation":[{"name":"Royal Papworth Hospital Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3764-3563","authenticated-orcid":false,"given":"Joanna","family":"Pepke\u2010Zaba","sequence":"additional","affiliation":[{"name":"Royal Papworth Hospital Cambridge UK"},{"name":"University of Cambridge Cambridge Cambridgeshire United\u00a0Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3530-3808","authenticated-orcid":false,"given":"Stephen P","family":"Hoole","sequence":"additional","affiliation":[{"name":"Royal Papworth Hospital Cambridge UK"},{"name":"University of Cambridge Cambridge Cambridgeshire United\u00a0Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00449-2023"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02828-2020"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-1767759"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2025-003532"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.019470"}],"container-title":["Pulmonary Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pul2.70419","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pul2.70419","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pul2.70419","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T07:46:15Z","timestamp":1792050375000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pul2.70419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":5,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/pul2.70419"],"URL":"https:\/\/doi.org\/10.1002\/pul2.70419","archive":["Portico"],"relation":{},"ISSN":["2045-8940","2045-8940"],"issn-type":[{"value":"2045-8940","type":"print"},{"value":"2045-8940","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2026-08-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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