{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:16:15Z","timestamp":1790424975848,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Rapid Comm Mass Spectrometry"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Phenolic endocrine\u2010disrupting chemicals (EDCs), including alkylphenols (APs) and bisphenols (BPs), pose significant environmental and public health concerns due to their widespread presence in aquatic ecosystems and potential toxicity at trace concentrations. This study developed and validated a sensitive analytical method for the simultaneous determination of 16 phenolic EDCs in environmental waters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The method involves sample acidification to pH\u20092, hydrophilic\u2013lipophilic balance (HLB), solid\u2010phase extraction (SPE), and ultra\u2010performance liquid chromatography\u2013tandem mass spectrometry (UPLC\u2013MS\/MS) analysis with negative electrospray ionization (ESI\u2212). Systematic optimization revealed that an alkaline mobile phase (methanol\/0.1% ammonia) significantly enhanced the ionization efficiency of phenolic compounds, improving sensitivity by approximately an order of magnitude compared to acidic conditions. Chromatographic separation was optimized using an ACQUITY UPLC BEH C\n                      <jats:sub>18<\/jats:sub>\n                      column, which provided superior peak shapes and improved retention of hydrophobic compounds.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Acidification of samples prior to SPE was critical for maximizing analyte recovery (57.9%\u201394.2%). The validated method demonstrated outstanding analytical performance, achieving low detection limits (0.01\u20130.4\u2009ng\/L), excellent linearity (\n                      <jats:italic>R<\/jats:italic>\n                      \u2009=\u20090.991\u20130.999) across a broad concentration range (1.0\u201350.0\u2009\u03bcg\/L) and high precision (RSDs\u2009=\u20091.3%\u201313.6%). Application of the method to environmental samples collected from rivers, wastewater treatment plants, and landfill leachates identified eight target compounds, with alkylphenols detected at higher concentrations than BPs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This reliable and robust method provides a valuable tool for monitoring trace levels of phenolic EDCs in diverse aquatic environments, supporting technically comprehensive environmental assessments and regulatory compliance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rcm.10155","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T01:45:12Z","timestamp":1760492712000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Trace Determination of 16 Phenolic Endocrine\u2010Disrupting Chemicals in Environmental Waters: A Validated SPE\u2013UPLC\u2013MS\/MS Approach"],"prefix":"10.1002","volume":"40","author":[{"given":"Bao","family":"Song","sequence":"first","affiliation":[{"name":"Guangxi Research Academy of Environmental Sciences  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinting","family":"Wang","sequence":"additional","affiliation":[{"name":"Guangxi Research Academy of Environmental Sciences  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anchen","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangxi Research Academy of Environmental Sciences  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongxue","family":"Lei","sequence":"additional","affiliation":[{"name":"Guangxi Research Academy of Environmental Sciences  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuelong","family":"Qin","sequence":"additional","affiliation":[{"name":"Guangxi Research Academy of Environmental Sciences  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui","family":"Pan","sequence":"additional","affiliation":[{"name":"Guangxi Research Academy of Environmental Sciences  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangzhao","family":"Sun","sequence":"additional","affiliation":[{"name":"Guangxi Research Academy of Environmental Sciences  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3330-1718","authenticated-orcid":false,"given":"Shujun","family":"Zhong","sequence":"additional","affiliation":[{"name":"Guangxi Research Academy of Environmental Sciences  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0FO02324H"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2011.04.010"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph120404141"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2023.122295"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-012-1236-y"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.5985\/emcr.20210013"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.5b05387"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2023.120310"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3724\/SP.J.1123.2014.02012"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/07373937.2011.645413"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2015.12.017"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2003.09.035"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.4491\/eer.2008.13.4.216"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5AN00415B"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2021.107098"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac302789c"},{"key":"e_1_2_6_18_1","first-page":"517","article-title":"Ecological Risk Assessment of Nonylphenol in Coastal Waters of China Based on Species Sensitivity Distribution Model","volume":"215","author":"Gao P.","year":"2019","journal-title":"Chemosphere"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/C2AN36022E"},{"issue":"402","key":"e_1_2_6_20_1","first-page":"962","article-title":"Determination of Phenolic Endocrine Disrupting Chemicals and Acidic Pharmaceuticals in Surface Water of the Pearl Rivers in South China by Gas Chromatography\u2010Negative Chemical Ionization\u2010Mass Spectrometry","volume":"407","author":"Zhao J. 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