{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T04:48:54Z","timestamp":1772772534667,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2003,6,6]],"date-time":"2003-06-06T00:00:00Z","timestamp":1054857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rapid Comm Mass Spectrometry"],"published-print":{"date-parts":[[2003,7,30]]},"abstract":"Abstract<\/jats:title>\n \n Four barbiturates (barbital, allobarbital, phenobarbital and butalbital) were analysed using high\u2010speed analytical countercurrent chromatography (HSACCC) and high\u2010performance liquid chromatography (HPLC) interfaced with mass spectrometry, using negative mode atmospheric pressure chemical ionisation (APCI). The polar biphasic solvent system of butyronitrile\/acetonitrile\/water (1:1:1) was used, in the upper\u2010stationary, lower\u2010mobile mode of operation, at a flow rate of 1\u2009mL\/min and a rotational speed of 1200\u2009rpm, equating to an applied \u2018\n g<\/jats:italic>\n \u2019\u2010field of 177\u2009\n g<\/jats:italic>\n . The fractional stationary phase retention (\n S<\/jats:italic>\n \n F<\/jats:italic>\n <\/jats:sub>\n ) was 0.58. Representative mass spectral data are presented from the HPLC and the HSACCC analyses. Structural information was obtained using source\u2010induced fragmentation at increased source block voltages. The effect of increasing\n g<\/jats:italic>\n \u2010field on chromatographic resolution is illustrated using the binary base system of butyronitrile\/water (1:1), under electrospray ionisation. Copyright \u00a9 2003 John Wiley & Sons, Ltd.\n <\/jats:p>","DOI":"10.1002\/rcm.1086","type":"journal-article","created":{"date-parts":[[2003,7,2]],"date-time":"2003-07-02T06:03:08Z","timestamp":1057125788000},"page":"1565-1572","source":"Crossref","is-referenced-by-count":21,"title":["Application of atmospheric pressure chemical ionisation mass spectrometry in the analysis of barbiturates by high\u2010speed analytical countercurrent chromatography"],"prefix":"10.1002","volume":"17","author":[{"given":"Jonathan J.","family":"Jones","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huw","family":"Kidwell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David E.","family":"Games","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,6,6]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"444","volume-title":"Goodman and Gilman's The Pharmacological Basis of Therapeutics","author":"Rall T","year":"1990"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(96)00707-8"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/10826079408013374"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/12.6.322"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0231(19980715)12:13<890::AID-RCM251>3.0.CO;2-X"},{"key":"e_1_2_7_7_2","series-title":"Chemical Analysis","volume-title":"High Speed Countercurrent Chromatography","author":"Ito Y","year":"1996"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/np0004395"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf0000833"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1369-703X(02)00219-X"},{"key":"e_1_2_7_11_2","author":"Janaway L","year":"2003","journal-title":"J Liquid Chromatogr. Rel. 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