{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:15:02Z","timestamp":1791317702532,"version":"4.3.1"},"reference-count":11,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2003,11,5]],"date-time":"2003-11-05T00:00:00Z","timestamp":1067990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rapid Comm Mass Spectrometry"],"published-print":{"date-parts":[[2003,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The process of metabolite identification is essential to the drug discovery and development process; this is usually achieved by liquid chromatography\/tandem mass spectrometry (LC\/MS\/MS) or a combination of liquid chromatography\/mass spectrometry (LC\/MS) and nuclear magnetic resonance (NMR) spectroscopy. Metabolite identification is, however, a time\u2010consuming process requiring an experienced skilled scientist. Multivariate statistical analysis has been used in the field of metabonomics to elucidate differences in endogenous biological profiling due to a toxic effect or a disease state. In this paper we show how a combination of liquid chromatography\/time\u2010of\u2010flight mass spectrometry (LC\/TOFMS) and multivariate statistical analysis can be used to detect drug metabolites in a biological fluid with no prior knowledge of the compound administered. Copyright \u00a9 2003 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/rcm.1250","type":"journal-article","created":{"date-parts":[[2003,12,2]],"date-time":"2003-12-02T09:12:54Z","timestamp":1070356374000},"page":"2632-2638","source":"Crossref","is-referenced-by-count":176,"title":["Use of liquid chromatography\/time\u2010of\u2010flight mass spectrometry and multivariate statistical analysis shows promise for the detection of drug metabolites in biological fluids"],"prefix":"10.1002","volume":"17","author":[{"given":"Robert S.","family":"Plumb","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris L.","family":"Stumpf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer H.","family":"Granger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Castro\u2010Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John N.","family":"Haselden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon J.","family":"Dear","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,11,5]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/00498250050078020"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(97)00688-2"},{"key":"e_1_2_5_4_2","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/S0090-9556(25)06734-0","volume":"23","author":"Mutlib AE","year":"1995","journal-title":"Drug Metab. 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