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Demeclocycline, another tetracycline molecule not reported for its usage in honey, was used as internal standard to quantify the four analytes. The sample preparation entails a clean\u2010up on an Oasis HLB solid\u2010phase extraction cartridge and analyses were realised by LC\/MS\/MS in selected reaction monitoring mode. The stability of tetracyclines was checked under various storage conditions at \u221220, +4 and +20\u00b0C (both under dark and light exposures). Indeed, tetracyclines are not stable molecules and the epimerisation phenomenon was evaluated in this work. Appropriate correction factors of the MS\/MS responses of each epimer were studied for each of the four tetracyclines to accurately quantify them. Moreover, the matrix effects encountered during the LC\/MS\/MS analyses were also studied in spiked experiments from blank honey samples of various geographical origins and different flower types. 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