{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T04:55:36Z","timestamp":1778907336205,"version":"3.51.4"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,11,28]],"date-time":"2005-11-28T00:00:00Z","timestamp":1133136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rapid Comm Mass Spectrometry"],"published-print":{"date-parts":[[2006,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The recently developed technique of desorption electrospray ionization (DESI) has been applied to the rapid analysis of controlled substances. Experiments have been performed using a commercial ThermoFinnigan LCQ Advantage MAX ion\u2010trap mass spectrometer with limited modifications. Results from the ambient sampling of licit and illicit tablets demonstrate the ability of the DESI technique to detect the main active ingredient(s) or controlled substance(s), even in the presence of other higher\u2010concentration components. Full\u2010scan mass spectrometry data provide preliminary identification by molecular weight determination, while rapid analysis using the tandem mass spectrometry (MS\/MS) mode provides fragmentation data which, when compared to the laboratory\u2010generated ESI\u2010MS\/MS spectral library, provide structural information and final identification of the active ingredient(s). The consecutive analysis of tablets containing different active components indicates there is no cross\u2010contamination or interference from tablet to tablet, demonstrating the reliability of the DESI technique for rapid sampling (one tablet\/min or better). Active ingredients have been detected for tablets in which the active component represents less than 1% of the total tablet weight, demonstrating the sensitivity of the technique. The real\u2010time sampling of\n                    <jats:italic>cannabis<\/jats:italic>\n                    plant material is also presented. Published in 2005 by John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/rcm.2267","type":"journal-article","created":{"date-parts":[[2005,11,28]],"date-time":"2005-11-28T08:47:20Z","timestamp":1133167640000},"page":"53-60","source":"Crossref","is-referenced-by-count":90,"title":["Rapid analysis of controlled substances using desorption electrospray ionization mass spectrometry"],"prefix":"10.1002","volume":"20","author":[{"given":"Sandra E.","family":"Rodriguez\u2010Cruz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,28]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0379-0738(99)00062-6"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0379-0738(02)00190-1"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2004.04.034"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1104404"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1039\/B418697D"},{"key":"e_1_2_6_7_2","author":"Chen H","year":"2005","journal-title":"Anal. Chem."},{"key":"e_1_2_6_8_2","unstructured":"CodyRB DurstHD LarameeJA.17th Sanibel Conf. Mass Spectrometry Clearwater Beach FL 2005."},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2675315"},{"key":"e_1_2_6_10_2","volume-title":"Electrospray Ionization Mass Spectrometry\u2014Fundamentals, Instrumentation and Applications","author":"Cole RB","year":"1997"},{"key":"e_1_2_6_11_2","volume-title":"Physicians' Desk Reference","year":"2004"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0379-0738(83)90101-9"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0379-0738(84)90149-X"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0379-0738(98)00083-8"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1520\/JFS14636J"}],"container-title":["Rapid Communications in Mass Spectrometry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcm.2267","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T09:36:41Z","timestamp":1761471401000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/rcm.2267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11,28]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1,15]]}},"alternative-id":["10.1002\/rcm.2267"],"URL":"https:\/\/doi.org\/10.1002\/rcm.2267","archive":["Portico"],"relation":{},"ISSN":["0951-4198","1097-0231"],"issn-type":[{"value":"0951-4198","type":"print"},{"value":"1097-0231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,11,28]]}}}