{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:20:38Z","timestamp":1762100438944,"version":"build-2065373602"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,1,5]],"date-time":"2006-01-05T00:00:00Z","timestamp":1136419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rapid Comm Mass Spectrometry"],"published-print":{"date-parts":[[2006,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Two opium alkaloids, noscapine and papaverine, show good response as [M+H]\n                    <jats:sup>+<\/jats:sup>\n                    ions in positive ion electrospray mass spectrometry and atmospheric pressure chemical ionisation mass spectrometry. The two compounds exhibit markedly different fragmentation pathways and behaviour under multistage mass spectrometry (MS\n                    <jats:sup>n<\/jats:sup>\n                    ), with papaverine displaying a wealth of ions in MS\n                    <jats:sup>2<\/jats:sup>\n                    and noscapine providing a single dominant ion at each stage of MS\n                    <jats:sup>n<\/jats:sup>\n                    prior to MS\n                    <jats:sup>4<\/jats:sup>\n                    . Elucidation of the fragmentation pathways using the MS\n                    <jats:sup>n<\/jats:sup>\n                    capability of the ion trap was aided by spraying the analytes in\n                    <jats:sup>2<\/jats:sup>\n                    H\n                    <jats:sub>2<\/jats:sub>\n                    O to incorporate an isotopic label. Simplex optimisation allowed optimum trapping and fragmentation parameters to be determined, leading to a six\u2010fold improvement in response for one transition and a seven\u2010fold improvement for one transition sequence. Copyright \u00a9 2006 John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/rcm.2325","type":"journal-article","created":{"date-parts":[[2006,1,5]],"date-time":"2006-01-05T08:28:31Z","timestamp":1136449711000},"page":"473-480","source":"Crossref","is-referenced-by-count":28,"title":["Atmospheric pressure ionisation mass spectrometric fragmentation pathways of noscapine and papaverine revealed by multistage mass spectrometry and in\u2010source deuterium labelling"],"prefix":"10.1002","volume":"20","author":[{"given":"James R.","family":"Wickens","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Sleeman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brendan J.","family":"Keely","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,5]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200390185"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/13556210120056553"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/25.6.431"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0379-0738(99)00033-X"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0379-0738(96)02086-5"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0379-0738(01)00541-2"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0379-0738(99)00201-7"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(01)01069-X"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1039\/a808573k"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac00219a003"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0231(20000130)14:2<112::AID-RCM841>3.0.CO;2-0"},{"key":"e_1_2_5_13_2","first-page":"87","volume-title":"Mass Spectrometry Principles and Applications","author":"De Hoffmann E","year":"2002"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.287"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.1007"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.1264"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.799"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9888(199704)32:4<351::AID-JMS512>3.0.CO;2-Y"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00093a047"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja01005a022"},{"key":"e_1_2_5_21_2","first-page":"371","volume-title":"Interpretation of Mass Spectra","author":"McLafferty FW","year":"1993"}],"container-title":["Rapid Communications in Mass Spectrometry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Frcm.2325","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcm.2325","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T10:23:40Z","timestamp":1761474220000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/rcm.2325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1,5]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,2,15]]}},"alternative-id":["10.1002\/rcm.2325"],"URL":"https:\/\/doi.org\/10.1002\/rcm.2325","archive":["Portico"],"relation":{},"ISSN":["0951-4198","1097-0231"],"issn-type":[{"type":"print","value":"0951-4198"},{"type":"electronic","value":"1097-0231"}],"subject":[],"published":{"date-parts":[[2006,1,5]]}}}