{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:16:46Z","timestamp":1791191806251,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2006,3,20]],"date-time":"2006-03-20T00:00:00Z","timestamp":1142812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rapid Comm Mass Spectrometry"],"published-print":{"date-parts":[[2006,4,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    An analytical method for the simultaneous determination of codeine, morphine and 6\u2010acetylmorphine (6AM) in human oral fluid was developed. The method involves liquid\u2010liquid extraction in Toxitubes A\u00ae, derivatization with 99:1 (v\/v)\n                    <jats:italic>N,O<\/jats:italic>\n                    \u2010bis(trimethylsilyl)trifluoroacetamide (BSTFA)\/trimethylchlorosilane (TMCS), and gas chromatography\/mass spectrometry with positive chemical ionization (GC\/PCI\u2010MS) determination. The detector response was linear over the concentration range 30\u2013500\u2009ng\/mL with coefficients of correlation higher than 0.99. The precision was acceptable with coefficients of variation less than 7.5%. The limits of detection achieved were 0.7\u2009ng\/mL for codeine, 2.0\u2009ng\/mL for morphine, and 0.6\u2009ng\/mL for 6AM. The method proposed was applied to 80 oral fluid samples from opiates users, 98% of which were positive for the three analytes. Human oral fluid is a suitable biological fluid for the determination of opiates by GC\/PCI\u2010MS. Copyright \u00a9 2006 John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/rcm.2449","type":"journal-article","created":{"date-parts":[[2006,3,20]],"date-time":"2006-03-20T07:16:55Z","timestamp":1142839015000},"page":"1288-1292","source":"Crossref","is-referenced-by-count":22,"title":["Use of gas chromatography\/mass spectrometry with positive chemical ionization for the determination of opiates in human oral fluid"],"prefix":"10.1002","volume":"20","author":[{"given":"Pamela","family":"C\u00e1mpora","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Mar\u00eda","family":"Bermejo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jes\u00fas","family":"Tabernero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Purificaci\u00f3n","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,3,20]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/16.1.1"},{"key":"e_1_2_6_3_2","first-page":"198","volume-title":"Advances in Analytical Toxicology","author":"Caddy B","year":"1984"},{"key":"e_1_2_6_4_2","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1093\/clinchem\/39.4.670","volume":"39","author":"Goldberger BA","year":"1993","journal-title":"Clin. Chem."},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(94)85218-9"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4347(92)80526-V"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/14.1.1"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/27.5.270"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpt1978245563"},{"key":"e_1_2_6_10_2","first-page":"255","volume":"4","author":"Wood JH","year":"1982","journal-title":"Methods Find Exp. Clin. Pharmacol."},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(97)00572-0"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1993.tb18346.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004140050119"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004140050239"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00315096"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/23.6.452"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/19.6.359"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(96)00088-6"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/24.7.536"}],"container-title":["Rapid Communications in Mass Spectrometry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Frcm.2449","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcm.2449","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:03:33Z","timestamp":1761487413000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/rcm.2449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3,20]]},"references-count":18,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2006,4,30]]}},"alternative-id":["10.1002\/rcm.2449"],"URL":"https:\/\/doi.org\/10.1002\/rcm.2449","archive":["Portico"],"relation":{},"ISSN":["0951-4198","1097-0231"],"issn-type":[{"value":"0951-4198","type":"print"},{"value":"1097-0231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,3,20]]}}}