{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T20:57:17Z","timestamp":1761512237276,"version":"build-2065373602"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2006,5,4]],"date-time":"2006-05-04T00:00:00Z","timestamp":1146700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rapid Comm Mass Spectrometry"],"published-print":{"date-parts":[[2006,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Eight novel polyamides containing\n                    <jats:italic>N<\/jats:italic>\n                    \u2010methylpyrrole were designed to target the sequence (5\u2032\u2010CTGCATATAAGCAG\u20103\u2032\/5\u2032\u2010CTGCTTATATGCAG\u20103\u2032) of the TATA box element of the HIV\u20101 promoter DNA. The non\u2010covalent complexes of the promoter DNA and the polyamides were investigated by electrospray ionization (ESI) mass spectrometry, which provided strong evidence for the binding of the novel polyamides to the sequence of the TATA box element. It also revealed that polyamide 2 (PyPyPyPy\n                    <jats:italic>\u03b2<\/jats:italic>\n                    Dp), a potent binder of HIV\u20101 promoter DNA and a lead molecule for the design of new anti\u2010HIV\u20101 drugs, had the highest binding affinity with the TATA box element DNA among these polyamides by examining the stoichiometry and the selectivity. Copyright \u00a9 2006 John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/rcm.2508","type":"journal-article","created":{"date-parts":[[2006,5,4]],"date-time":"2006-05-04T12:30:09Z","timestamp":1146745809000},"page":"1736-1740","source":"Crossref","is-referenced-by-count":7,"title":["Investigation of non\u2010covalent complexes of HIV\u20101 promoter DNA and polyamides containing\n                    <i>N<\/i>\n                    \u2010methylpyrrole by electrospray ionization mass spectrometry"],"prefix":"10.1002","volume":"20","author":[{"given":"Huihui","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gu","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,5,4]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.3727\/000000001783992696"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0896(01)00262-0"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/365520a0"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/365512a0"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsb0298-104"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo000135n"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00092a087"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9888(199912)34:12<1328::AID-JMS889>3.0.CO;2-F"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja990684e"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/29.21.e103"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac011283w"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gnf081"},{"key":"e_1_2_6_14_2","first-page":"2072","author":"Rosu F","year":"2003","journal-title":"Chem. 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