{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:54:43Z","timestamp":1786978483197,"version":"build-2736575974"},"reference-count":16,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2006,8,21]],"date-time":"2006-08-21T00:00:00Z","timestamp":1156118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Medicine Science Foundation of Ningbo, Zhejiang Province, China","award":["2004056"],"award-info":[{"award-number":["2004056"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rapid Comm Mass Spectrometry"],"published-print":{"date-parts":[[2006,9,30]]},"abstract":"Abstract<\/jats:title>\n \n A rapid, sensitive and selective method for the simultaneous determination of bromadiolone, flocoumafen and brodifacoum in whole blood using warfarin as internal standard (IS) by high\u2010performance liquid chromatography coupled with electrospray ionization mass spectrometry (HPLC\/ESI\u2010MS) has been developed and validated. The target compounds were extracted from the whole blood with ethyl acetate and separated on an XDB C\n 18<\/jats:sub>\n column (150\u2009mm\u2009\u00d7\u20092.1\u2009mm i.d.\u2009\u00d7\u20095\u2009\u00b5m) by using a mobile phase consisting of 0.2% acetic acid\/methanol (12\/88, v\/v) at a constant flow rate of 0.50 mL\/min. The analytes were detected using negative ESI\u2010MS in the selected ion monitoring (SIM) mode. The molecular ions [M\uf8ffH]\n \u2212<\/jats:sup>\n of\n \n m\/z<\/jats:italic>\n <\/jats:bold>\n 527, 541,523 and 307 were selected for the quantification for bromadiolone, flocoumafen, brodifacoum and the IS, respectively. The calibration curves were linear (r\n 2<\/jats:sup>\n \u2009>\u20090.995) in the concentration range of 0.50\u2013100.00 ng\/mL. The method showed a satisfactory sensitivity (0.05\u20130.5 ng\/mL using 200 \u00b5L blood), precision (RSD\u2009<\u200911.9%), accuracy (recovery: 82.0\u201396.1%) and selectivity. This method was successfully applied to the determination of the analytes for the diagnoses of poisoned human beings and animals. 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