{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:46:18Z","timestamp":1762865178637,"version":"build-2065373602"},"reference-count":38,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2006,8,29]],"date-time":"2006-08-29T00:00:00Z","timestamp":1156809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rapid Comm Mass Spectrometry"],"published-print":{"date-parts":[[2006,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A new method is described for the qualitative and quantitative analysis of cyanide, a very short\u2010acting and powerful toxic agent, in human whole blood. It involves the conversion of cyanide into hydrogen cyanide and its subsequent headspace solid\u2010phase microextraction (HS\u2010SPME) and detection by gas chromatography\/mass spectrometry (GC\/MS) in selected ion monitoring (SIM) mode. Optimizing the conditions for the GC\/MS (type of column, injection conditions, temperature program) and SPME (choice of SPME fiber, effect of salts, adsorption and desorption times, adsorption temperature) led to the choice of a 75\u2010\u00b5m carboxen\/polydimethylsiloxane SPME fiber, with D\n                    <jats:sub>3<\/jats:sub>\n                    \u2010acetonitrile as internal standard, and a capillary GC column with a polar stationary phase. Method validation was carried out in terms of linearity, precision and accuracy in both aqueous solutions and blood. The limit of detection (LOD) and limit of quantitation (LOQ) were determined only in aqueous solutions. The assay is linear over three orders of magnitude (water 0.01\u201310, blood 0.05\u201310\u2009\u00b5g\/mL); and the LOD and LOQ in water were 0.006 and 0.01\u2009\u00b5g\/mL, respectively. Good intra\u2010 and inter\u2010assay precision was obtained, always &lt;8%. The method is simple, fast and sensitive enough for the rapid diagnosis of cyanide intoxication in clinical and forensic toxicology. Copyright \u00a9 2006 John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/rcm.2689","type":"journal-article","created":{"date-parts":[[2006,8,29]],"date-time":"2006-08-29T06:55:36Z","timestamp":1156834536000},"page":"2932-2938","source":"Crossref","is-referenced-by-count":42,"title":["An improved method for cyanide determination in blood using solid\u2010phase microextraction and gas chromatography\/mass spectrometry"],"prefix":"10.1002","volume":"20","author":[{"given":"Giampietro","family":"Frison","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavio","family":"Zancanaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donata","family":"Favretto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santo Davide","family":"Ferrara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,8,29]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"35","volume":"95","author":"Pasi A","year":"1985","journal-title":"J. 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