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Samples were obtained from 20\u2010week\u2010old male wild\u2010type Zucker lean, (fa\/fa) obese and lean\/(fa) animals and were analysed following protein precipitation, using acetonitrile, and derivatisation. Subsequent data analysis using principal components analysis (PCA) and orthogonal projection to latent structures (OPLS) revealed differences between the plasma metabolite profiles of the three strains, with those of the Zucker lean and the lean\/(fa) crosses being similar to each other whilst differing from the (fa\/fa) obese strain. 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