{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:26:41Z","timestamp":1791304001360,"version":"4.1.0"},"reference-count":64,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2006,10,17]],"date-time":"2006-10-17T00:00:00Z","timestamp":1161043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rapid Comm Mass Spectrometry"],"published-print":{"date-parts":[[2006,11,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>An objective means based on the carbon and nitrogen stable isotope analysis of five hairs per individual is presented for distinguishing between individuals with anorexia nervosa and\/or bulimia nervosa from non\u2010clinical individuals (i.e. clinically normal controls). Using discriminant analysis, an algorithm has been developed that provides both sensitivity and specificity of 80% in making diagnoses of individuals with these eating disorders. With further refinements, the results suggest that it may be also possible to distinguish between individuals with anorexia or bulimia. Finally, the study shows the value of conducting blind tests and using larger sample sizes of both control and treatment groups. Both groups are needed to validate the diagnostic value of a method and to provide measures of sensitivity and specificity of any diagnostic test. Copyright \u00a9 2006 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/rcm.2740","type":"journal-article","created":{"date-parts":[[2006,10,17]],"date-time":"2006-10-17T12:54:40Z","timestamp":1161089680000},"page":"3367-3373","source":"Crossref","is-referenced-by-count":103,"title":["An objective means of diagnosing anorexia nervosa and bulimia nervosa using\n                    <sup>15<\/sup>\n                    N\/\n                    <sup>14<\/sup>\n                    N and\n                    <sup>13<\/sup>\n                    C\/\n                    <sup>12<\/sup>\n                    C ratios in hair"],"prefix":"10.1002","volume":"20","author":[{"given":"Kent A.","family":"Hatch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan A.","family":"Crawford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda W.","family":"Kunz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.","family":"Thomsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis L.","family":"Eggett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen T.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beverly L.","family":"Roeder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,10,17]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-2466.1997.tb02692.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/106402601300187731"},{"key":"e_1_2_6_4_2","first-page":"2000","volume-title":"Diagnostic and Statistical Manual for Mental Disorders","author":"American Psychiatric Association","year":"1994"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291799002573"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12378-1"},{"key":"e_1_2_6_7_2","volume":"5","author":"Thomsen SR","year":"2000","journal-title":"Qual. Rep."},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1098-108X(199111)10:6<647::AID-EAT2260100604>3.0.CO;2-T"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.2477"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1017\/S002185960004853X"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-4403(03)00066-9"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-7037(84)90204-7"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00442-003-1270-z"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-7037(81)90244-1"},{"key":"e_1_2_6_15_2","first-page":"389","volume-title":"Natural Variations in 15N in the Marine Environment","author":"Owens NJP","year":"1987"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8644(199904)108:4<409::AID-AJPA3>3.0.CO;2-E"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.2307\/1369361"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00442-003-1429-7"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.2090"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.1925"},{"key":"e_1_2_6_21_2","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1093\/ajcn\/40.2.251","volume":"40","author":"Huse DM","year":"1984","journal-title":"Am. J. Clin. Nutr."},{"key":"e_1_2_6_22_2","first-page":"51","volume":"16","author":"Dunker KLL","year":"2003","journal-title":"Braz. J. Nutr."},{"key":"e_1_2_6_23_2","first-page":"265","volume":"35","author":"Beumont PJV","year":"1981","journal-title":"J. Hum. Nutr."},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/1098-108X(200011)28:3<284::AID-EAT5>3.0.CO;2-G"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/oa.655"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-7037(84)90091-7"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6344217"},{"key":"e_1_2_6_28_2","first-page":"59","volume-title":"Investigations of Ancient Human Tissue","author":"Ambrose SH","year":"1993"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/bms.1200120911"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-7037(87)90151-7"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-7037(78)90199-0"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0305-4403(91)90066-X"},{"key":"e_1_2_6_33_2","first-page":"85","volume":"12","author":"Jones RJ","year":"1981","journal-title":"Search"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1080\/00085030.1989.10757414"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-02894-0_5"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.13.3.559"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/bms.1200090906"},{"key":"e_1_2_6_38_2","first-page":"200","volume":"11","author":"Webb Y","year":"1980","journal-title":"Search"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8644(199605)100:1<23::AID-AJPA3>3.0.CO;2-E"},{"key":"e_1_2_6_40_2","unstructured":"O'ConnellTC.D. Phil. Thesis University of Oxford Oxford 1996."},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/0883-2927(92)90033-Y"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.706"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1999.0360"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/57.12.M797"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1139\/z01-007"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.1708"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1520\/JFS13007J"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-3782(98)00099-1"},{"key":"e_1_2_6_49_2","doi-asserted-by":"publisher","DOI":"10.2307\/1368808"},{"key":"e_1_2_6_50_2","doi-asserted-by":"publisher","DOI":"10.1139\/z99-105"},{"key":"e_1_2_6_51_2","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.1042"},{"key":"e_1_2_6_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-7037(57)90024-8"},{"key":"e_1_2_6_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/303685a0"},{"key":"e_1_2_6_54_2","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1001\/jama.1994.03510290071040","volume":"271","author":"Jaeschke R","year":"1994","journal-title":"J. Am. Med. Assoc."},{"key":"e_1_2_6_55_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03510330081039"},{"key":"e_1_2_6_56_2","doi-asserted-by":"publisher","DOI":"10.1086\/381165"},{"key":"e_1_2_6_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2004.12.009"},{"key":"e_1_2_6_58_2","doi-asserted-by":"publisher","DOI":"10.1080\/03670244.1986.9990922"},{"key":"e_1_2_6_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9422(81)85134-5"},{"key":"e_1_2_6_60_2","doi-asserted-by":"publisher","DOI":"10.2307\/1310735"},{"key":"e_1_2_6_61_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3040.1992.tb01660.x"},{"key":"e_1_2_6_62_2","first-page":"1","volume-title":"Stable Isotopes in Ecology and Environmental Science","author":"Lajtha K","year":"1994"},{"key":"e_1_2_6_63_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.1330930203"},{"key":"e_1_2_6_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2004.02.009"},{"key":"e_1_2_6_65_2","doi-asserted-by":"publisher","DOI":"10.1002\/erv.2400020406"}],"container-title":["Rapid Communications in Mass Spectrometry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Frcm.2740","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcm.2740","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:33:19Z","timestamp":1761489199000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/rcm.2740"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,17]]},"references-count":64,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2006,11,30]]}},"alternative-id":["10.1002\/rcm.2740"],"URL":"https:\/\/doi.org\/10.1002\/rcm.2740","archive":["Portico"],"relation":{},"ISSN":["0951-4198","1097-0231"],"issn-type":[{"value":"0951-4198","type":"print"},{"value":"1097-0231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10,17]]}}}