{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T03:26:33Z","timestamp":1772594793204,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2007,8,20]],"date-time":"2007-08-20T00:00:00Z","timestamp":1187568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rapid Comm Mass Spectrometry"],"published-print":{"date-parts":[[2007,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A new screening procedure for 18 narcotics in urine for anti\u2010doping purposes has been developed using liquid chromatography\/triple quadrupole mass spectrometry (LC\/MS). Electrospray ionization (ESI) was used as interface. Infusion experiments were performed for all substances to investigate their mass spectrometric behaviour in terms of selecting product specific ions. These product ions were then used to develop a tandem mass spectrometric method using selected reaction monitoring (SRM). For the LC\/MS analysis, chromatography was performed on an octadecylsilane column. The total run time of the chromatographic method was 5.5\u2009min. For the sample preparation prior to LC\/MS analysis, the urine samples were liquid\u2010liquid extracted at pH 9.5 after overnight enzymatic hydrolysis. Two extraction solvents were evaluated: dichloromethane\/methanol 9\/1 (v\/v), which is currently used for the extraction of narcotics, and diethyl ether, used for the extraction of steroids. With diethyl ether the detection limits for all compounds ranged between 0.5 and 20\u2009ng\/mL and with the mixture containing dichloromethane the detection limits ranged between 0.5 and 10\u2009ng\/mL. Taking into account the minimum required performance limits of the World Anti\u2010Doping Agency of 200\u2009ng\/mL for narcotics, diethyl ether can also be considered as extraction solvent for narcotics. Finally, the described method was applied to the analysis of urine samples previously found to contain narcotics by our routine gas chromatography\/mass spectrometry (GC\/MS) method. Copyright \u00a9 2007 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/rcm.3142","type":"journal-article","created":{"date-parts":[[2007,8,20]],"date-time":"2007-08-20T18:48:18Z","timestamp":1187635698000},"page":"3015-3023","source":"Crossref","is-referenced-by-count":22,"title":["Development of a qualitative liquid chromatography\/tandem mass spectrometric method for the detection of narcotics in urine relevant to doping analysis"],"prefix":"10.1002","volume":"21","author":[{"given":"Koen","family":"Deventer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar J.","family":"Pozo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Van Eenoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frans T.","family":"Delbeke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,8,20]]},"reference":[{"key":"e_1_2_6_2_2","unstructured":"WADA.The World Anti\u2010Doping Code The 2006 Prohibited List International Standard 2006."},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(96)00276-9"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac026111t"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2004.11.027"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.1934"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.1098"},{"key":"e_1_2_6_8_2","unstructured":"Eurachem Working Group.Eurachem A laboratory guide to method validation and related topics 1998."},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2670(93)80274-O"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.1157"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)00390-3"},{"key":"e_1_2_6_12_2","volume-title":"Vloeistofchromatografie","author":"Baars B","year":"2001"},{"key":"e_1_2_6_13_2","volume-title":"Clarke's Isolation and Identification of Drugs, in Pharmaceuticals, Body Fluids and Post\u2010mortem Material","year":"1986"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/29.7.704"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.496"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.2372"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac971078"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0231(19990630)13:12<1175::AID-RCM639>3.0.CO;2-0"},{"key":"e_1_2_6_19_2","volume-title":"Fundamentals of Drug Metabolism and Drug Disposition","author":"La Du B","year":"1971"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1570-0232(02)00910-8"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/jms.921"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2006.04.042"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-003-2414-z"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1570-0232(01)00616-X"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1255\/ejms.761"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(01)00029-9"},{"key":"e_1_2_6_27_2","volume-title":"The Merck Index","year":"2001"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(96)00496-3"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/28.6.422"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2004.09.024"}],"container-title":["Rapid Communications in Mass Spectrometry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Frcm.3142","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcm.3142","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T11:36:52Z","timestamp":1761478612000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/rcm.3142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8,20]]},"references-count":29,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2007,9,30]]}},"alternative-id":["10.1002\/rcm.3142"],"URL":"https:\/\/doi.org\/10.1002\/rcm.3142","archive":["Portico"],"relation":{},"ISSN":["0951-4198","1097-0231"],"issn-type":[{"value":"0951-4198","type":"print"},{"value":"1097-0231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8,20]]}}}