{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T13:39:21Z","timestamp":1769261961212,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2007,10,5]],"date-time":"2007-10-05T00:00:00Z","timestamp":1191542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rapid Comm Mass Spectrometry"],"published-print":{"date-parts":[[2007,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    An ultra\u2010performance liquid chromatography coupled with tandem mass spectrometry (UPLC\/MS\/MS) method was developed to screen and confirm multi\u2010class veterinary drug residues in pig tissues including pig kidney, liver and meat. Twenty\u2010one drugs of two different classes including seven tetracyclines and four types of quinolones (quinoline, naphthyridine, pyridopyrimidine and cinoline) were determined simultaneously in a single run. The homogenized sample tissues were extracted with EDTA\u2013McIlvaine buffer solution and further purified using a polymer\u2010based Oasis HLB solid\u2010phase extraction (SPE) cartridge. An ACQUITY UPLC\u2122 BEH C\n                    <jats:sub>18<\/jats:sub>\n                    column was used to separate the analytes followed by tandem mass spectrometry using an electrospray ionization source. MS data acquisition was performed in the positive ion multiple reaction monitoring mode, selecting two ion transitions for each target compound. Recovery studies were performed at different fortification levels. The overall average recoveries from pig muscle, kidney, and liver fortified with quinolones and tetracyclines at three levels ranged from 80.2 to 117.8% based on the use of matrix\u2010fortified calibration with the coefficients of variation ranging from 2.1 to 17.8% (n\u2009=\u20096). The limits of quantitation (LOQs) of quinolones and tetracyclines in different tissues ranged from 0.03\u20134.50 \u00b5g\/kg and 0.16\u201310.00 \u00b5g\/kg, respectively. The effects of the extraction solvent, SPE cartridge, elution solvent and sample matrix on the analyte recovery as well as the effects of the mobile phase composition and column temperature on the chromatographic behavior were also studied. Copyright \u00a9 2007 John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/rcm.3236","type":"journal-article","created":{"date-parts":[[2007,10,5]],"date-time":"2007-10-05T11:47:02Z","timestamp":1191584822000},"page":"3487-3496","source":"Crossref","is-referenced-by-count":45,"title":["Multi\u2010class confirmatory method for analyzing trace levels of tetracyline and quinolone antibiotics in pig tissues by ultra\u2010performance liquid chromatography coupled with tandem mass spectrometry"],"prefix":"10.1002","volume":"21","author":[{"given":"Bing","family":"Shao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofei","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongning","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianying","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoming","family":"Tu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,10,8]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-2670(02)00751-1"},{"key":"e_1_2_6_3_2","first-page":"269","volume-title":"Drug Residues in Foods","author":"Botsoglou NA","year":"2001"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1079\/095442200108729106"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.99107s6907"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-006-1012-2"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2005.05.005"},{"key":"e_1_2_6_8_2","first-page":"257","volume-title":"Analysis of Veterinary Drug Residues","author":"Li JS","year":"2002"},{"key":"e_1_2_6_9_2","unstructured":"Available:http:\/\/www.hnfeed.com\/feed\/14\/200604131575.html accessed 16 June 2007; (in Chinese)."},{"key":"e_1_2_6_10_2","unstructured":"Commission Decision 2377\/90\/EEC Off. 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