{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:01:46Z","timestamp":1761512506344,"version":"build-2065373602"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,2,18]],"date-time":"2008-02-18T00:00:00Z","timestamp":1203292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rapid Comm Mass Spectrometry"],"published-print":{"date-parts":[[2008,3,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A gas chromatography\/negative chemical ionization mass spectrometry (GC\/NCIMS) method using headspace solid\u2010phase microextraction (HS\u2010SPME) was developed for the determination of trichloroethylene (TCE) in blood, liver, kidney, lung and brain. The method was optimized with respect to several parameters including extraction time, extraction temperature, desorption time and salt addition. The method showed good linearity over the range of 0.025\u201325\u2009ng\/mL in blood and 0.075\u201375\u2009ng\/g in tissues with correlation coefficient (R\n                    <jats:sup>2<\/jats:sup>\n                    ) values higher than 0.99. The precision and accuracy for intra\u2010day and inter\u2010day measurements were less than 10%. The relative recoveries of all matrices were greater than 52%. Samples showed no significant loss during 8\u2009h in the autosampler and following three freeze\/thaw cycles. Validation results demonstrated that selected\u2010ion monitoring of the\n                    <jats:sup>35<\/jats:sup>\n                    Cl and\n                    <jats:sup>37<\/jats:sup>\n                    Cl isotopes using NCI resulted in reliable and sensitive quantitation. This validated method was successfully applied to study the toxicokinetics of TCE following oral administration of extremely low doses of this potential human carcinogen to small test animals (rats). Copyright \u00a9 2008 John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/rcm.3426","type":"journal-article","created":{"date-parts":[[2008,2,18]],"date-time":"2008-02-18T06:46:35Z","timestamp":1203317195000},"page":"797-806","source":"Crossref","is-referenced-by-count":10,"title":["Trace level determination of trichloroethylene in biological samples by headspace solid\u2010phase microextraction gas chromatography\/negative chemical ionization mass spectrometry"],"prefix":"10.1002","volume":"22","author":[{"given":"Yongzhen","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srinivasa","family":"Muralidhara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James V.","family":"Bruckner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael G.","family":"Bartlett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,2,21]]},"reference":[{"volume-title":"Solid Phase Microextraction, Theory and Practice","year":"1997","author":"Pawliszyn J","key":"e_1_2_6_2_2"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/jms.606"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-1247-9_1"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)00309-5"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/adic.200590088"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1039\/b511201j"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0231(19991115)13:21<2133::AID-RCM764>3.0.CO;2-J"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-006-0715-8"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/24.1.22"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02290316"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2006.11.106"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(98)00515-5"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-2797(02)00255-7"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2006.09.009"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2005.05.035"},{"key":"e_1_2_6_17_2","unstructured":"ATSDR.ATSDR Toxicological Profile for Trichloroethylene (updated) Agency for Toxic Substances Disease Registry: Atlanta 1997."},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.488"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/es061553y"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.00108s2241"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1006\/faat.1997.2312"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.00108s2343"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.2307\/3434223"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.3109\/10408448909037475"},{"key":"e_1_2_6_25_2","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1289\/ehp.00108s2177","volume":"108","author":"Lash LH","year":"2002","journal-title":"Environ. Health Perspect."},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1021\/tx00043a001"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(81)90338-0"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(80)90011-3"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1996.0165"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2006.04.029"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2005.12.039"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1570-0232(03)00216-2"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1080\/02652030500391929"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2006.01.096"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-005-0227-y"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/jms.262"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/58.12.1440"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(99)00282-0"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1570-0232(02)00546-9"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1081\/CI-200048062"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2005.03.009"},{"key":"e_1_2_6_42_2","unstructured":"U.S. Department of Health and Human Services Food and Drug Administration.Guidance for Industry Bioanalytical Method Validation2001."},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfg212"}],"container-title":["Rapid Communications in Mass Spectrometry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Frcm.3426","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcm.3426","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T15:13:49Z","timestamp":1761491629000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/rcm.3426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2,21]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,3,30]]}},"alternative-id":["10.1002\/rcm.3426"],"URL":"https:\/\/doi.org\/10.1002\/rcm.3426","archive":["Portico"],"relation":{},"ISSN":["0951-4198","1097-0231"],"issn-type":[{"type":"print","value":"0951-4198"},{"type":"electronic","value":"1097-0231"}],"subject":[],"published":{"date-parts":[[2008,2,21]]}}}